Protein kinase A modulates A‐type potassium currents of larval zebrafish (Danio rerio) white muscle fibres

Abstract

PKA modulates the A-type K(+) current in zebrafish skeletal muscle and affects action potential properties. Our results provide new insights into the role of A-type K(+) channels in muscle physiology.

Epidermal growth factor differentially regulates activin subunits in the zebrafish ovarian follicle cells via diverse signaling pathways

“…To determine whether PKA is also involved in EGF regulation of activin expression, we tested the effect of a PKA inhibitor (H89) on EGF effects. H89 at 10 lM has been shown to be effective in inhibiting PKA in the zebrafish (Coutts et al, 2009;Garcia-Lopez et al, 2010;Wang and Ge, 2003). Similar to the effects of MAPK3/1, p38 MAPK and PKC pathway inhibitors, the inhibition of PKA activity by H89 also led to a partial reduction of EGF-stimulated expression of inhbaa ($50%).…”

Melanocortin type 4 receptor–mediated inhibition of A-type K+ current enhances sensory neuronal excitability and mechanical pain sensitivity in rats

“…In hippocampal pyramidal neurons, activation of PKA by 8-bromo-cAMP significantly decreased I A (36). Similarly, 3-isobutyl-1-methylxanthine stimulation of PKA down-regulated the peak current density of I A (37). In contrast, PKA inducer mimicked the response of serotonin 1D receptor activator and was shown to stimulate I A in TG neurons (38).…”

Trace amine-associated receptor 1 regulation of Kv1.4 channels in trigeminal ganglion neurons contributes to nociceptive behaviors

“…In superficial dorsal horn neurons, stimulation of PKA was found to significantly reduce I A [ 47 ]. Similarly, activation of PKA by forskolin reduced the peak amplitude of I A in rat hippocampal CA1 neurons [ 46 ] as well as in zebrafish white skeletal muscle fibers [ 61 ]. In contrast, a PKA inducer mimicking the effect of neuromedin U receptors, which enhanced I A in dorsal root ganglion neurons, has been reported [ 35 ].…”