Protein Kinase C Inhibition Rescues Manic-Like Behaviors and Hippocampal Cell Proliferation Deficits in the Sleep Deprivation Model of Mania

Abrial, Erika; Bétourné, Alexandre; Etiévant, Adeline; Lucas, George L.; Scarna, H.; Lambás‐Señas, Laura; Haddjeri, Nasser

doi:10.1093/ijnp/pyu031

Cited by 43 publications

(48 citation statements)

References 68 publications

(83 reference statements)

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“…Increased PKC activity is observed in the PFC of rats submitted to AMPH administration [47,48]. AMPH-induced hyperlocomotion has been shown to be reversed [7] and prevented [49] by intraperitoneal administration of lithium or tamoxifen (TMX), a selective estrogen receptor modulator with PKC inhibitory activity [8,50].…”

Section: Pkc Translocation and Activitymentioning

confidence: 99%

“…Sleep-deprived rats display paradoxical hyperlocomotion, increased penile erection, and insomnia [48]. Sleep-deprived animals did not display manic phenotype when they were pretreated with lithium or TMX or their combination [52].…”

Section: Pkc Translocation and Activitymentioning

confidence: 99%

“…Intraperitoneal administration of quercetin also prevented PSD-induced hyperlocomotion [53]. Interestingly, PSD-induced behavioral changes were reversed by a one-time administration of lithium about 1 h prior to behavioral testing without affecting baseline activity [48]. At cellular level, PSD decreased hippocampal cell proliferation as indicated by decreased bromodeoxyuridine labeling [48].…”

Section: Pkc Translocation and Activitymentioning

confidence: 99%

“…Interestingly, PSD-induced behavioral changes were reversed by a one-time administration of lithium about 1 h prior to behavioral testing without affecting baseline activity [48]. At cellular level, PSD decreased hippocampal cell proliferation as indicated by decreased bromodeoxyuridine labeling [48]. Again, single administration of lithium increased BrdU-labeled hippocampal neurons in sleep-deprived rats highlighting potent neuroprotective actions of lithium [48].…”

Section: Pkc Translocation and Activitymentioning

confidence: 99%

“…At cellular level, PSD decreased hippocampal cell proliferation as indicated by decreased bromodeoxyuridine labeling [48]. Again, single administration of lithium increased BrdU-labeled hippocampal neurons in sleep-deprived rats highlighting potent neuroprotective actions of lithium [48]. …”

Section: Pkc Translocation and Activitymentioning

confidence: 99%

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Role of Protein Kinase C in Bipolar Disorder: A Review of the Current Literature

et al. 2017

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Bipolar disorder (BD) is a major health problem. It causes significant morbidity and imposes a burden on the society. Available treatments help a substantial proportion of patients but are not beneficial for an estimated 40-50%. Thus, there is a great need to further our understanding the pathophysiology of BD to identify new therapeutic avenues. The preponderance of evidence pointed towards a role of protein kinase C (PKC) in BD. We reviewed the literature pertinent to the role of PKC in BD. We present recent advances from preclinical and clinical studies that further support the role of PKC. Moreover, we discuss the role of PKC on synaptogenesis and neuroplasticity in the context of BD. The recent development of animal models of BD, such as stimulant-treated and paradoxical sleep deprivation, and the ability to intervene pharmacologically provide further insights into the involvement of PKC in BD. In addition, the effect of PKC inhibitors, such as tamoxifen, in the resolution of manic symptoms in patients with BD further points in that direction. Furthermore, a wide variety of growth factors influence neurotransmission through several molecular pathways that involve downstream effects of PKC. Our current understanding identifies the PKC pathway as a potential therapeutic avenue for BD.

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Section: Pkc Translocation and Activitymentioning

confidence: 99%

Section: Pkc Translocation and Activitymentioning

confidence: 99%

Section: Pkc Translocation and Activitymentioning

confidence: 99%

Section: Pkc Translocation and Activitymentioning

confidence: 99%

Section: Pkc Translocation and Activitymentioning

confidence: 99%

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Role of Protein Kinase C in Bipolar Disorder: A Review of the Current Literature

et al. 2017

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SERINC2increases the risk of bipolar disorder in the Chinese population

Yang

Chen

Cheng

et al. 2021

Depression and Anxiety

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Background Although common variants in a large collection of patients are associated with increased risk for bipolar disorder (BD), studies have only been able to predict 25%‐45% of risks, suggesting that lots of variants that contribute to the risk for BD haven't been identified. Our study aims to identify novel BD risk genes. Methods We performed whole‐exome sequencing of 27 individuals from 6 BD multi‐affected Chinese families to identify candidate variants. Targeted sequencing of one of the novel risk genes, SERINC2, in additional sporadic 717 BD patients and 312 healthy controls (HC) validated the association. Magnetic resonance imaging (MRI) were performed to evaluate the effect of the variant to brain structures from 213 subjects (4 BD subjects from a multi‐affected family, 130 sporadic BD subjects and 79 HC control). Results BD pedigrees had an increased burden of uncommon variants in extracellular matrix (ECM) and calcium ion binding. By large‐scale sequencing we identified a novel recessive BD risk gene, SERINC2, which plays a role in synthesis of sphingolipid and phosphatidylserine (PS). MRI image results show the homozygous nonsense variant in SERINC2 affects the volume of white matter in cerebellum. Conclusions Our study identified SERINC2 as a risk gene of BD in the Chinese population.

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Galanin and neuropeptide Y interactions elicit antidepressant activity linked to neuronal precursor cells of the dentate gyrus in the ventral hippocampus

Borroto-Escuela

Pita-Rodríguez

Fores-Pons

et al. 2020

Journal Cellular Physiology

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A need for new antidepressants is necessary since traditional antidepressants have several flaws. Neuropeptide Y(NPY) Y1 receptor (NPYY1R) and galanin (GAL) receptor 2 (GALR2) interact in several regions of the limbic system, including the hippocampus. The current study assesses the antidepressant effects induced by GALR2 and NPYY1R coactivation, together with the evaluation of cell proliferation through 5‐Bromo‐2'‐deoxyuridine expression within the dentate gyrus of the ventral hippocampus (vDG). We employed in situ proximity ligation assay to manifest GALR2/NPYY1R heteroreceptor complexes. Additionally, the expression pattern of GALR2 and the activation of the extracellular‐regulated kinases (ERK) pathway after GALR2 and NPYY1R costimulation in cell cultures were examined. GALR2 and NPYY1R coactivation resulted in sustained antidepressant behaviors in the FST after 24 h, linked to increased cell proliferation in the vDG. Moreover, an increased density of GALR2/NPYY1R heteroreceptor complexes was observed in vDG, on doublecortin‐expressing neuroblasts. Recruitment of the GALR2 expression to the plasma membrane was observed upon the coactivation of GALR2 and NPYY1R in cell cultures, presumably associated to the enhanced effects on the activation of ERK pathway. GALR2 may promote the GALR2/NPYY1R heteroreceptor complexes formation in the ventral hippocampus. It may induce a transformation of cell proliferation toward a neuronal lineage by enhancement of ERK pathway. Thus, it may give the mechanism for the antidepressant behavior observed. These results may provide the basis for the development of heterobivalent agonist pharmacophores, targeting GALR2/NPYY1R heteromers, especially in the neuronal precursor cells of the dentate gyrus in the ventral hippocampus for the novel treatment of depression.

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Protein Kinase C Inhibition Rescues Manic-Like Behaviors and Hippocampal Cell Proliferation Deficits in the Sleep Deprivation Model of Mania

Cited by 43 publications

References 68 publications

Role of Protein Kinase C in Bipolar Disorder: A Review of the Current Literature

Role of Protein Kinase C in Bipolar Disorder: A Review of the Current Literature

SERINC2increases the risk of bipolar disorder in the Chinese population

Galanin and neuropeptide Y interactions elicit antidepressant activity linked to neuronal precursor cells of the dentate gyrus in the ventral hippocampus

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