Protein kinase C regulates mitochondrial motility

Nekrasova, O. E.; Kulik, A. V.; Минин, А. А.

doi:10.1134/s199074780702002x

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…The movement of mitochondria depends on cytoskeleton, which is composed of actin filaments, intermediate filaments, and microtubules [4]. They move rapidly along tubulin and actin filaments in cellular mitochondria of which processes are regulated by protein kinases [5,6]. Based on their morphological and dynamic characteristics, mitochondria can adjust their shape, number, and orientation according to the developmental needs of plant cells [7,8].…”

Section: Introductionmentioning

confidence: 99%

Specific Changes in Morphology and Dynamics of Plant Mitochondria under Abiotic Stress

Tang

Zhu

2022

Horticulturae

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As the global climate continues to warm and the greenhouse effect intensifies, plants are facing various abiotic stresses during their growth and development. In response to changes in natural environment, plant mitochondria regulate their functions through morphological and dynamic changes. Mitochondria are highly dynamic organelles with the ability to continuously cleavage and fuse, regulating dynamic homeostatic processes in response to the needs of organism growth and the changes in external environmental conditions. In this review, we introduced the structure of the outer and inner mitochondrial membrane and discussed the relevant factors that influence the morphological changes in mitochondria, including proteins and lipids. The morphological and dynamic changes in mitochondria under various abiotic stresses were also revisited. This study aims to discuss a series of changes in plant mitochondrial ultrastructure under abiotic stress. It is very important that we analyze the association between plant mitochondrial functions and morphological and dynamic changes under stress to maintain mitochondrial homeostasis and improve plant stress resistance. It also provides a new idea for plant modification and genetic breeding under the dramatic change in global natural environment.

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Section: Introductionmentioning

confidence: 99%

Specific Changes in Morphology and Dynamics of Plant Mitochondria under Abiotic Stress

Tang

Zhu

2022

Horticulturae

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“…Changes in the dynamics of MC under prolonged stress and acute hypoxic hypoxia of different genesis lead to the development of mitochondrial dys function: a decrease in the maximum respiration rate and ADP stimulated oxygen uptake, as well as a substantial reduction in the activity of creatine kinase and the level of cytochrome c. The antiapoptotic protein Bcl 2 is translo cated from the inner to the outer mitochondrial mem brane [4,6,10].…”

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confidence: 99%

Structural and dynamic changes in mitochondria of rat myocardium under acute hypoxic hypoxia: Role of mitochondrial ATP-dependent potassium channel

Rozova

Mankovskaya

Mironova

2015

Biochemistry Moscow

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The ultrastructure and spatial localization of mitochondria (MC) in the myocardium of rats exposed to a 30-min hypoxic hypoxia were investigated. The mitochondrial structure was found to undergo changes; however, marked necrotic injuries were not observed. Changes occurring in the myocardium are aimed at the intensification of energy processes. This shows up as an increase in the number of MC in the subsarcolemmal zone of the myocardium and changes in the surface of the sublemmal membrane due to its bending around mitochondria, which improves the diffusion of oxygen into MC. In addition, the division of MC is enhanced, which partially explains the increase in their total number. In structurally altered MC with intact membrane, electron dense formations with small diameter appear, which probably represent newly formed organelles (microMC). In normoxia, changes of this kind do not occur. It was found that the ATP-dependent K+ channel is involved in the regulation of the morphological state of MC under hypoxic hypoxia. The activator of the channel diazoxide increases the number of newly formed microMC, and the channel inhibitor 5HD significantly prevents their formation. Possible mechanisms of structural and dynamic changes in rat myocardial MC under acute hypoxic hypoxia are discussed.

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