2021
DOI: 10.1101/2021.07.20.453051
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Protein kinase Cδ is essential for the IgG response against T cell-independent type 2 antigens and commensal bacteria

Abstract: Antigens (Ags) with multivalent and repetitive structure elicit IgG production in a T cell-independentmanner. However, the mechanisms by which such T cell-independent type-2 (TI-2) Ags induce IgG responses remain obscure. Here we report that BCR engagement with a TI-2 Ag but not with a T cell dependent (TD) Ag was able to induce the transcription of activation-induced cytidine deaminase (AID) and efficient class switching to IgG3 upon co-stimulation with IL-1 or IFN-α. TI-2 Ags strongly induced the phosphoryla… Show more

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