Protein Kinases as Potential Targets Contribute to the Development of Agrochemicals

Abstract

Using agrochemicals against pest insects, fungi, and weeds plays a major part in maintaining and improving crop yields, which helps to solve the issue of food security. Due to the limited targets and resistance of agrochemicals, protein kinases are regarded as attractive potential targets to develop new agrochemicals. Recently, a lot of investigations have shown the extension of agrochemicals by targeting protein kinases, implying an increasing concern for this kind of method. However, few people have summarized and discussed the targetability of protein kinases contributing to the development of agrochemicals. In this work, we introduce the research on protein kinases as potential targets used in crop protection and discuss the prospects of protein kinases in the field of agrochemical development. This study may not only provide guidance for the contribution of protein kinases to the development of agrochemicals but also help nonprofessionals such as students learn and understand the role of protein kinases quickly.

Nitrogen deficiency tolerance conferred by introgression of a QTL derived from wild emmer into bread wheat

“…TRIDC5BG005520 belongs to the p21-activated kinases ( PAKs ), a family of protein kinases that play essential roles in various cellular processes, including signal transduction, cytoskeletal organization, and plant stress responses (Bokoch 2003 ). PAKs can be involved in nutrient signaling and uptake processes (Sun et al 2022 ; Tian et al 2023 ).…”

ZIF-8@Hydroxyapatite Composite as a High Potential Material for Prolonged Delivery of Agrochemicals

“…Excessive use of agrochemicals is degrading ecosystem quality (living beings, soils, and groundwaters), ultimately affecting human health. The major issues related with the extensive/excessive use of agrochemicals are (i) growing population (projected to be 9.7 billion in 2050), (ii) poor efficacy (between 10 and 75 % do not reach their target), , (iii) high environmental impact (contaminating water, soil, and air), and (iv) the development of resistant straights . However, the use of agrochemicals (9.8 million tons of N-based fertilizers and 1.1 million tons of P-based fertilizers were used in agriculture across the European Union only in 2021) is crucial to combat pests and supply the lack of nutrients in soil, thus obtaining high yield productions.…”

“…The major issues related with the extensive/excessive use of agrochemicals are (i) growing population (projected to be 9.7 billion in 2050), 1 (ii) poor efficacy (between 10 and 75 % do not reach their target), 2 , 3 (iii) high environmental impact (contaminating water, soil, and air), 4 and (iv) the development of resistant straights. 5 However, the use of agrochemicals (9.8 million tons of N-based fertilizers and 1.1 million tons of P-based fertilizers were used in agriculture across the European Union only in 2021) 6 is crucial to combat pests and supply the lack of nutrients in soil, thus obtaining high yield productions. The actual scenario of their inefficient use (2 million tons per year in 2014) 7 makes it necessary to develop more efficient and less toxic methods against pests and infections, while improving crop productivity.…”

Layered Double Hydroxides for Regulating Phosphate in Water to Achieve Long-Term Nutritional Management

“…The rapid growth of the world’s population results in a rising demand for agricultural production. , It is estimated that more than 690 million people suffered from hunger in 2019, , and the number of hungry people may have risen to more than 820 million by the end of 2020 . Therefore, there is an emerging call for innovation in crop production to avoid food scarcity. − To avoid deforestation in new agricultural areas, fertilizer management is a practical way to enhance crop productivity.…”