Protein Kinases Signaling in Pancreatic Beta-cells Death and Type 2 Diabetes

Engin, Ayşe Başak

doi:10.1007/978-3-030-49844-3_8

Cited by 5 publications

(4 citation statements)

References 256 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whereas in other group with impaired PKB, the glucose levels increased and exhibited resistance towards insulin. This study depicted that the condition of insulin resistance is connected with the signalling effect of PKB (Engin et al, 2021) [44] . 3.…”

Section: Types Of Diabetes Mellitusmentioning

confidence: 90%

“…The phosphorylation result into protein substrates called protein kinase B (PKB) and a type of protein kinase C (PKC). This PKB produced is responsible for initiating glycogenesis and decrease in the production of glucose from hepatic system (Engin et al, 2021) [44] . An experiment was conduct on mice in 2010 to analyse the effect of PKB on blood glucose levels.…”

Section: Types Of Diabetes Mellitusmentioning

confidence: 99%

See 1 more Smart Citation

Study on the anti-diabetic properties of functional foods: A review

Haldua

2024

Pharma Innovation

View full text Add to dashboard Cite

The number of diabetic populations is increasing with much higher rate than predicted by various research authorities from various countries. Such drastic peak in diabetic population observed could be to changing lifestyle and unhealthy eating habits of majority of population. Mortality rates concerning with diabetes mellitus are higher in low-income countries due to lack of medical care and infrastructure. Diabetes mellitus is more dangerous when it invites other related complications like organ damage, retina and kidney damage, cardiovascular diseases and lack in the efficiency of nervous system. Various medicines are available which can administer orally or intravenously. These medications are efficient in reducing blood glucose levels of the body but in the same time they send signals to nervous system to stop the production of insulin permanently over a period of time as insulin is available in enough amounts from external sources. People tend to become dependent over medications for life time. In recent times, awareness regarding the clinical benefits of natural foods have been observed among researchers in order to treat diseases like diabetes mellitus and numerous natural foods which are antidiabetic in nature. These foods inhabit hypoglycaemic compounds which helps in reducing blood glucose levels and trigger the production of insulin naturally. This study focuses on nutritional aspects, in-vitro and in vivo studies conducted on pumpkin, flaxseeds and oats specifically, in order to prove their hypoglycaemic effect on human body. The exact mechanism and pathways behind this hypoglycaemic effect is difficult to establish, still few researches have predicted the most probable mechanism and pathways which have been discussed.

show abstract

Section: Types Of Diabetes Mellitusmentioning

confidence: 90%

Section: Types Of Diabetes Mellitusmentioning

confidence: 99%

Study on the anti-diabetic properties of functional foods: A review

Haldua

2024

Pharma Innovation

View full text Add to dashboard Cite

show abstract

“…Epidemiological research ndings have suggested that the prevalence of diabetes is 12.8% among adults living in China and it is even higher among population aged over 50, which have caused heavy economic and social burden [2]. The pathogenesis of T2D is mainly due to the insulin resistance in skeletal muscle [3]. Skeletal muscle is responsible for insulin-stimulated glucose tolerance; the resistant of skeletal muscle to insulin stimulation has been recognized as a crucial step in the progress of diabetes [3].…”

Section: Introductionmentioning

confidence: 99%

“…The pathogenesis of T2D is mainly due to the insulin resistance in skeletal muscle [3]. Skeletal muscle is responsible for insulin-stimulated glucose tolerance; the resistant of skeletal muscle to insulin stimulation has been recognized as a crucial step in the progress of diabetes [3]. T2D subjects with muscle disorders demonstrates worse glycemic control [4,5], which may partly attribute to the dysfunction of myosin glycosylation and mitochondria in muscles to process glucose [5].…”

Section: Introductionmentioning

confidence: 99%

Free Fatty Acid Is Associated With Muscle Dysfunction in Chinese Adults With Type 2 Diabetes

Fu¹,

Sun²,

Mu³

et al. 2021

Preprint

View full text Add to dashboard Cite

Purpose: Muscle dysfunction is considered as a sign of poor prognosis in patients with type 2 diabetes (T2D). Thus, early detection of muscle disorders is particularly important in T2D population. For free fatty acid (FFA) is known as a clinical indicator of metabolic diseases and muscle function, hence, we aimed to investigate whether FFA could serve as a biomarker for muscle function.Methods: There are totally 160 adult subjects with T2D were characterized and analyzed in this study. Muscle mass and function were measured by walking speed, grip strength and height-adjusted appendicular skeletal muscle mass (SMI). Logistic regression was applied to explore the correlation of FFA with muscle indicators. Receiver operating characteristic (ROC) curves were utilized to conduct the diagnostic value of FFA.Results: FFA was negatively correlated with SMI (r = -0.347, P = 1.0E-05), grip strength (r = -0.313, P = 7.1E-05) and walking speed (r = -0.167, P = 0.039). Notably, the relationships between FFA and SMI and walking speed remained significant even after adjusting for age, sex, body mass index (BMI) and hemoglobin A1C (HbA1c). The combination of conventional indicators including age, BMI and HbA1c provided discrimination effect of low grip strength with an AUC of 0.648, low walking speed with an AUC of 0.714. Importantly, when FFA was added to the model, the value of ROC curve was further improved, with an AUC of 0.785 for low grip strength, 0.755 for low walking speed.Conclusions: The current study demonstrated a negative correlation of FFA with muscle indicators in adult T2D patients after adjusting for HbA1c. FFA may play an important role in the pathological process of muscle dysfunction in adults with T2D.

show abstract

Free fatty acids are associated with muscle dysfunction in Chinese adults with type 2 diabetes

Sun

et al. 2022

Endocrine

View full text Add to dashboard Cite

Protein Kinases Signaling in Pancreatic Beta-cells Death and Type 2 Diabetes

Cited by 5 publications

References 256 publications

Study on the anti-diabetic properties of functional foods: A review

Study on the anti-diabetic properties of functional foods: A review

Free Fatty Acid Is Associated With Muscle Dysfunction in Chinese Adults With Type 2 Diabetes

Free fatty acids are associated with muscle dysfunction in Chinese adults with type 2 diabetes

Contact Info

Product

Resources

About