Protein kinases: The key contributors in pathogenesis and treatment of nonalcoholic fatty liver disease-derived hepatocellular carcinoma

Design, Synthesis, and Biological Evaluation of Newly Synthesized Cinnamide-Fluorinated Containing Compounds as Bioactive Anticancer Agents

“…Cancer has remained a critical health issue around the world and is the second fatal cause after cardiovascular diseases. , Protein phosphorylation is among the most abundant and important cellular signaling post-translational modification in the biological system . This reversible enzymatic reaction plays a pivotal role in nearly all signal translational pathways and is carried out by a special class of proteins called protein kinases. , The functional annotation of this phosphorylation process in a growing number of human diseases and physiological conditions underscores the relevance of protein kinases in medicine. , Protein kinases catalyze the phosphorylation of target proteins by transferring the γ-phosphate group of adenosine triphosphate (ATP) onto the side-chain alcohol group of serine, threonine, and tyrosine amino acid residues . Misregulation of protein kinase signaling by kinase hyperactivation or mutation commonly results in human diseases including cancer .…”

“… 4 , 5 The functional annotation of this phosphorylation process in a growing number of human diseases and physiological conditions underscores the relevance of protein kinases in medicine. 6 , 7 Protein kinases catalyze the phosphorylation of target proteins by transferring the γ-phosphate group of adenosine triphosphate (ATP) onto the side-chain alcohol group of serine, threonine, and tyrosine amino acid residues. 8 Misregulation of protein kinase signaling by kinase hyperactivation or mutation commonly results in human diseases including cancer.…”

Pathologically successful conversion hepatectomy for advanced giant hepatocellular carcinoma after multidisciplinary therapy: A case report and review of literature

“…It has seriously threatened the life and health of Chinese people, and hepatocellular carcinoma (HCC) accounts for the majority of of this disease[ 2 ]. Several liver diseases, such as hepatitis virus infection, alcoholism, and nonalcoholic fatty liver disease, are often associated with the development of HCC[ 3 - 5 ]. When diagnosed, more than 80% of patients are in the advanced stage when they are diagnosed and have obvious resistance to conventional chemotherapy and radiotherapy[ 6 - 8 ].…”