Protein-lipid relationships in human plasma

Barr, David P.; Russ, Ella M.; Eder, Howard A.

doi:10.1016/0002-9343(51)90183-0

Cited by 594 publications

(41 citation statements)

References 9 publications

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“…Increased abundance of apoA-I correlates inversely with the incidence of coronary arterial disease (3,4). This beneficial feature of the protein arises from its pivotal role in a normal physiologic process called reverse cholesterol transport (5).…”

mentioning

confidence: 99%

Effects of Glucose and Insulin on Rat Apolipoprotein A-I Gene Expression

Murao

Wada

Nakamura

et al. 1998

Journal of Biological Chemistry

116

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We have examined the regulation of apolipoprotein A-I (apoA-I) gene expression in response to glucose and insulin. In Hep G2 cells, endogenous apoA-I mRNA was suppressed by one-half or induced 2-fold following 48 h of exposure to high concentrations of glucose (22.4 mM) or insulin (100 microunits/ml), respectively, compared with control. Transcriptional activity of the rat apoA-I promoter (؊474 to ؊7) in Hep G2 cells paralleled endogenous mRNA expression, and this activity was dependent on the dose of glucose or insulin. Deletional analysis showed that a 50-base pair fragment spanning ؊425 to ؊376 of the promoter mediated the effects of both insulin and glucose. Within this DNA fragment there is a motif (؊411 to ؊404) that is homologous to a previously identified insulin response core element (IRCE). Mutation of this motif abolished not only the induction of the promoter by insulin but also abrogated its suppression by glucose. Electrophoretic mobility shift assay analysis of nuclear extracts from Hep G2 cells revealed IRCE binding activity that formed a duplex with radiolabeled probe. The IRCE binding activity correlated with insulin induction of apoA-I expression. In summary, our data show that glucose decreases and insulin increases apoA-I promoter activity. This effect appears to be mediated by a single cis-acting element.

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mentioning

confidence: 99%

Effects of Glucose and Insulin on Rat Apolipoprotein A-I Gene Expression

Murao

Wada

Nakamura

et al. 1998

Journal of Biological Chemistry

116

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“…Low mean levels of HOL are one of the metabolic characteristics of patients with IHO: This was recognized over 20 years ago (Nikkila 1953, Barr et al 1951), confirmed more recently , Carlson & Ericsson 1975, Berg et al 1976, and was incorporated into an aetiological hypothesis by Miller & Miller (1975). Two ongoing prospective studies have indicated that low HOL concentration is predictive of increased cardiovascular risk (Gordon et al 1977a,b, Miller et al 1977; this risk factor status appears independent of other risk-related variables.…”

Section: High Density Lipoprotein (Hdl) Deficiencymentioning

confidence: 99%

Hypothesis into Theory – the Development of Aetiological Concepts of Ischaemic Heart Disease: A Review

Lewis

1978

J R Soc Med

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“…Long before, epidemiologic studies had found that low levels of high-density lipoprotein cholesterol (HDL-C) are strongly associated with an increased risk of CHD. As early as 1951, Barr et al [6]noted the relation between low levels of HDL-C and CHD. In 1986, the Framingham study confirmed the association between low HDL-C and CHD [7].…”

Section: Introductionmentioning

confidence: 99%

A Review of the Treatment Guidelines on the Management of Low Levels of High-Density Lipoprotein Cholesterol

Devroey¹,

Vantomme²,

Betz

et al. 2004

Cardiology

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This paper aims to review the guidelines on the importance given to high-density lipoprotein cholesterol (HDL-C) as a risk factor or as threshold and target level in the treatment of dyslipidemia. We developed a strategy with cholesterol-related key words to search for guidelines in the major databases. The Appraisal of Guidelines Research Evaluation (AGREE) instrument was used for the evaluation and inclusion of the guidelines. In total nine guidelines were selected. Almost all selected guidelines consider low HDL-C as a marker of an increased risk for coronary heart disease. However, only few guidelines use the level of HDL-C as a threshold or target level for the treatment of dyslipidemia. The guidelines provide only little information on the management of patients with treatment-induced low HDL-C. Instead of using total cholesterol (TC) or low-density lipoprotein cholesterol (LDL-C) we consider the use of the ratios of TC to HDL-C or LDL-C to HDL-C as a threshold as well as a target for treatment.

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Protein-lipid relationships in human plasma

Cited by 594 publications

References 9 publications

Effects of Glucose and Insulin on Rat Apolipoprotein A-I Gene Expression

Effects of Glucose and Insulin on Rat Apolipoprotein A-I Gene Expression

Hypothesis into Theory – the Development of Aetiological Concepts of Ischaemic Heart Disease: A Review

A Review of the Treatment Guidelines on the Management of Low Levels of High-Density Lipoprotein Cholesterol

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