Protein-lipid relationships in human plasma

Russ, Ella M.; Eder, Howard A.; Barr, David P.

doi:10.1016/0002-9343(51)90182-9

Cited by 224 publications

(35 citation statements)

References 21 publications

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“…Then, in 1951, Russ, Eder, and Barr (29) at the New York Hospital-Cornell Medical Center, using the methods developed in the Cohn/Oncley laboratory, made the important finding that women before menopause had consistently higher blood levels of the ␣ -lipoprotein than did men. They speculated that this difference might be related to the lower incidence of coronary artery disease in premenopausal women, and time has certainly proved them right.…”

Section: The Birth Of the Lipoproteinsmentioning

confidence: 99%

Thematic review series: The Pathogenesis of Atherosclerosis. An interpretive history of the cholesterol controversy: part I

Steinberg

2004

Journal of Lipid Research

169

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This is the first of a series of reviews of the controversy that swirled around the "lipid hypothesis" of atherosclerosis for so many years. Today, in the era of the statins, there is no longer any doubt about the value of decreasing blood cholesterol levels. In fact, "the lower the better" is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is worth telling for its own sake and because remembering it may help us avoid similar mistakes in the future.

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Section: The Birth Of the Lipoproteinsmentioning

confidence: 99%

Thematic review series: The Pathogenesis of Atherosclerosis. An interpretive history of the cholesterol controversy: part I

Steinberg

2004

Journal of Lipid Research

169

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“…This observation lends support to the concept that the ratio of total cholesterol to lipid phosphorus is by far of greater importance than either serum total cholesterol or serum lipid phosphorus in assessing the genesis of atherosclerosis. 4' 7, 8 From Gofman's observations that the Sf [10][11][12][13][14][15][16][17][18][19][20] with atherosclerosis, the level of serum total cholesterol may be employed as a guide to the molecules do not change in men after the midthirties, but do continue to rise steadily ill women. Perhaps the female has additional protective mechanisms which, in spite of the high concentration of Sf 10-20 molecules in the serum, exert a salutary effect.…”

Section: Total Cholesterol-lipid Phosphorusmentioning

confidence: 99%

The Interrelationships of Serum Lipids in Men and Women Past Sixty-Five Years of Age and Their Bearing on Atherosclerosis

Gertler

Oppenheimer

1953

Circulation

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“…6 Many behavioral and pharmacological variables influence HDLC levels. Higher HDLC levels have been associated with female gender, 7 estrogens, 8 - 10 exercise, 11 nicotinic acid, 12 and alcohol, 13 whereas lower HDLC levels have been found associated with hypertriglyceridemia, 14 obesity, 15 smoking, 16 and use of anabolic steroids. 17 - 20 Many of these variables have also been associated with subsequent risk of ischemic heart disease.…”

mentioning

confidence: 99%

Epidemiological correlates of high density lipoprotein subfractions, apolipoproteins A-I, A-II, and D, and lecithin cholesterol acyltransferase. Effects of smoking, alcohol, and adiposity.

Haffner¹,

Applebaum-Bowden²,

Wahl³

et al. 1985

Arteriosclerosis

122

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Recent data suggest that the protection against ischemic heart disease afforded by high density lipoprotein (HDL) cholesterol (C) may be concentrated in the HDL 2 subfraction. To examine the behavioral correlates of the HDL subfractions, we recalled 33 men and 17 women of a random sample from the Pacific Northwest Bell Telephone Company Health Survey. Adiposity and very low density lipoprotein (VLDL) triglyceride were negatively correlated with HDL 2 C. Smoking was not correlated with HDL 2 C, but was negatively correlated with HDL 3 C (men, r s = -0.635, p = 0.001; women, r s = -0.534, p -0.014); this relationship was independent of alcohol consumption, adiposity, and VLDL triglyceride. Alcohol consumption was also more strongly related to HDL 3 C (men, r s = 0.248, p = 0.082; women, r s = 0.586, p = 0.007). Lecithin cholesterol acyltransferase (LCAT) mass was negatively related with HDL 2 C, but was positively correlated with HDL 3 C and apolipoprotein A-ll. Smoking was negatively correlated with LCAT mass. Since it is believed that HDL 3 C is not associated with the risk of ischemic heart disease and since both smoking and alcohol consumption may mainly affect HDL 3 C, the current study suggests that the increase in risk of ischemic heart disease with smoking and the possible decrease with alcohol consumption may be mediated through mechanisms other than their effects on HDLC. (Arteriosclerosis 5:169-177, March/April 1985)

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Protein-lipid relationships in human plasma

Cited by 224 publications

References 21 publications

Thematic review series: The Pathogenesis of Atherosclerosis. An interpretive history of the cholesterol controversy: part I

Thematic review series: The Pathogenesis of Atherosclerosis. An interpretive history of the cholesterol controversy: part I

The Interrelationships of Serum Lipids in Men and Women Past Sixty-Five Years of Age and Their Bearing on Atherosclerosis

Epidemiological correlates of high density lipoprotein subfractions, apolipoproteins A-I, A-II, and D, and lecithin cholesterol acyltransferase. Effects of smoking, alcohol, and adiposity.

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