Protein metabolism in insulin-treated gestational diabetes.

Butte, Nancy F.; Hsu, H W; Thotathuchery, Mary; Wong, William W.; Khoury, J.; Reeds, Peter J.

doi:10.2337/diacare.22.5.806

Cited by 35 publications

(47 citation statements)

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“…Some studies have reported that elevated plasma levels of branched-chain amino acids (BCAAs) also were associated with an increased risk of GDM [63,64] T2D [64,65], and insulin resistance [66]. In our present study, there were no significant differences in maternal plasma amino acid levels between GDM and non-GDM mothers.…”

Section: Fetal Metabolites Associated With Maternal Gdmcontrasting

confidence: 43%

Fetal Serum Metabolites Are Independently Associated with Gestational Diabetes Mellitus

Reichetzeder

Prehn

et al. 2018

Cell Physiol Biochem

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Background/Aims: Gestational diabetes (GDM) might be associated with alterations in the metabolomic profile of affected mothers and their offspring. Until now, there is a paucity of studies that investigated both, the maternal and the fetal serum metabolome in the setting of GDM. Mounting evidence suggests that the fetus is not just passively affected by gestational disease but might play an active role in it. Metabolomic studies performed in maternal blood and fetal cord blood could help to better discern distinct fetal from maternal disease interactions. Methods: At the time of birth, serum samples from mothers and newborns (cord blood samples) were collected and screened for 163 metabolites utilizing tandem mass spectrometry. The cohort consisted of 412 mother/child pairs, including 31 cases of maternal GDM. Results: An initial non-adjusted analysis showed that eight metabolites in the maternal blood and 54 metabolites in the cord blood were associated with GDM. After Benjamini-Hochberg (BH) procedure and adjustment for confounding factors for GDM, fetal phosphatidylcholine acyl-alkyl C 32:1 and proline still showed an independent association with GDM. Conclusions: This study found metabolites in cord blood which were associated with GDM, even after adjustment for established risk factors of GDM. To the best of our knowledge, this is the first study demonstrating an independent association between fetal

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Section: Fetal Metabolites Associated With Maternal Gdmcontrasting

confidence: 43%

Fetal Serum Metabolites Are Independently Associated with Gestational Diabetes Mellitus

Reichetzeder

Prehn

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…In addition, the GDM diagnostic criteria used varied among the studies. Two studies specified using O’Sullivan and Mahan criteria [19, 20], seven studies used Carpenter–Coustan criteria [21-27]; three studies referenced the World Health Organization [28-30], one study referenced the Fourth International Gestational Diabetes Workshop criteria, and four studies did not specify the GDM diagnostic criteria used [31-34]. …”

Section: Resultsmentioning

confidence: 99%

“…One study used amniotic fluid only [31], eight used maternal plasma only [19, 20, 22, 23, 25, 26, 29, 35], three used maternal serum only [21, 24, 30], two used maternal urine only [28, 34], one used both amniotic fluid and urine [33], and one used both maternal urine and plasma [32]. Three studies examined metabolite profiles in the setting of other prenatal disorders [28, 33, 34]; however, only data on women with GDM without these potential confounders were abstracted from these studies.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of metabolite profiling in gestational diabetes mellitus

2014

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Aims/hypothesis Gestational diabetes mellitus is associated with adverse maternal and fetal outcomes during, as well as subsequent to, pregnancy, including increased risk of type 2 diabetes and cardiovascular disease. Because of the importance of early risk stratification in preventing these complications, improved first-trimester biomarker determination for diagnosing gestational diabetes would enhance our ability to optimise both maternal and fetal health. Metabolomic profiling, the systematic study of small molecule products of biochemical pathways, has shown promise in the identification of key metabolites associated with the pathogenesis of several metabolic diseases, including gestational diabetes. This article provides a systematic review of the current state of research on biomarkers and gestational diabetes and discusses the clinical relevance of metabolomics in the prediction, diagnosis and management of gestational diabetes. Methods We conducted a systematic search of MEDLINE (PubMed) up to the end of February 2014 using the key term combinations of 'metabolomics,' 'metabonomics,' 'nuclear magnetic spectroscopy,' 'mass spectrometry,' 'metabolic profiling' and 'amino acid profile' combined (AND) with 'gestational diabetes'. Additional articles were identified through searching the reference lists from included studies. Quality assessment of included articles was conducted through the use of QUADOMICS. Results This systematic review included 17 articles. The biomarkers most consistently associated with gestational diabetes were asymmetric dimethylarginine and NEFAs. After QUADOMICS analysis, 13 of the 17 included studies were classified as 'high quality'. Conclusions/interpretation Existing metabolomic studies of gestational diabetes present inconsistent findings regarding metabolite profile characteristics. Further studies are needed in larger, more racially/ethnically diverse populations.

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“…Increased plasmatic glutamate levels have been found also in insulin-resistant non-obese subjects [174] and in gestational diabetes [175]. It is noteworthy that in these women, protein turnover was normalized by insulin treatment, but fasting and postprandial glutamate levels remained elevated despite the satisfactory glycemic control.…”

Section: Plasma Glutamate Levels In Different Pathologic Conditionsmentioning

confidence: 96%

“…Acta Diabetol (2012) 49:[167][168][169][170][171][172][173][174][175][176][177][178][179][180][181][182][183] …”

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The potential role of glutamate in the current diabetes epidemic

2012

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In the present article, we propose the perspective that abnormal glutamate homeostasis might contribute to diabetes pathogenesis. Previous reports and our recent data indicate that chronically high extracellular glutamate levels exert direct and indirect effects that might participate in the progressive loss of β-cells occurring in both T1D and T2D. In addition, abnormal glutamate homeostasis may impact all the three accelerators of the "accelerator hypothesis" and could partially explain the rising frequency of T1D and T2D.

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Protein metabolism in insulin-treated gestational diabetes.

Abstract: Protein turnover was normalized in insulin-treated women with GDM; however, fasting and postprandial plasma concentrations of amino acids were elevated in the antepartum and postpartum periods, despite satisfactory maternal glycemic control.

Cited by 35 publications

References 0 publications

Fetal Serum Metabolites Are Independently Associated with Gestational Diabetes Mellitus

Fetal Serum Metabolites Are Independently Associated with Gestational Diabetes Mellitus

A systematic review of metabolite profiling in gestational diabetes mellitus

The potential role of glutamate in the current diabetes epidemic

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