Protein–Metabolite Interactions Shape Cellular Metabolism and Physiology

Muralidhara, P; Ewald, Jennifer C.

doi:10.1007/978-1-0716-2624-5_1

Cited by 1 publication

(1 citation statement)

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“…In general, protein-metabolite interactions play a key role in controlling cellular processes due to the establishment of flexible and adaptive modules whose molecular behavior reflects the predominant way of energy production or pattern of signal transduction [7,8]. A detailed study and interpretation of interactions between metabolites and proteins allows for understanding the molecular basis of various (patho)physiological conditions and helps in the development of new approaches to the identification of potential therapeutic targets [9].…”

Section: Introductionmentioning

confidence: 99%

Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models

Kolotyeva,

Gilmiyarova,

Averchuk

et al. 2023

IJMS

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The development of brain in vitro models requires the application of novel biocompatible materials and biopolymers as scaffolds for controllable and effective cell growth and functioning. The “ideal” brain in vitro model should demonstrate the principal features of brain plasticity like synaptic transmission and remodeling, neurogenesis and angiogenesis, and changes in the metabolism associated with the establishment of new intercellular connections. Therefore, the extracellular scaffolds that are helpful in the establishment and maintenance of local microenvironments supporting brain plasticity mechanisms are of critical importance. In this review, we will focus on some carbohydrate metabolites—lactate, pyruvate, oxaloacetate, malate—that greatly contribute to the regulation of cell-to-cell communications and metabolic plasticity of brain cells and on some resorbable biopolymers that may reproduce the local microenvironment enriched in particular cell metabolites.

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Section: Introductionmentioning

confidence: 99%