Protein Methylation and Interaction with the Antiproliferative Gene, BTG2<sup>/TIS21/Pc3</sup>

Paik, Woon Ki; Kim, Sangduk; Lim, In Kyoung

doi:10.3349/ymj.2014.55.2.292

Cited by 4 publications

(4 citation statements)

References 102 publications

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“…The molecular mechanisms by which Btg1, as a transcriptional cofactor, regulates the cell cycle molecules in neural stem cells still needs to be clarified. However, it has been shown that Btg1 associates with Prmt1 and binds the transcriptional element Caf1/CNOT7, which have both been implicated in growth arrest [ 110, 111 ].…”

Section: Physical Exercise and Cell Cycle Kinetics In Adult Neurogenementioning

confidence: 99%

Control of the Cell Cycle in Adult Neurogenesis and its Relation with Physical Exercise

Farioli-Vecchioli

Tirone

2015

BPL

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In the adult brain the neurogenesis is mainly restricted to two neurogenic regions: newly generated neurons arise at the subventricular zone (SVZ) of the lateral ventricle and at the subgranular zone of the hippocampal subregion named the dentate gyrus. The hippocampus is involved in learning and memory paradigms and the generation of new hippocampal neurons has been hypothesized to be a pivotal form of plasticity involved in the process. Moreover the dysregulation of hippocampal adult neurogenesis has been recognized and could anticipate several varieties of brain disease such as Alzheimer disease, epilepsy and depression. Over the last few decades numerous intrinsic, epigenetic and environmental factors have been revealed to deeply influence the process of adult neurogenesis, although the underlying mechanisms remain largely unknown. Growing evidence indicates that physical exercise represents one of the main extrinsic factor able to profoundly increase hippocampal adult neurogenesis, by altering neurochemistry and function of newly generated neurons. The present review surveys how neurogenesis can be modulated by cell cycle kinetics and highlights the putative role of the cell cycle length as a key component of the beneficial effect of running for hippocampal adult neurogenesis, both in physiological conditions and in the presence of defective neurogenesis.

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Section: Physical Exercise and Cell Cycle Kinetics In Adult Neurogenementioning

confidence: 99%

Control of the Cell Cycle in Adult Neurogenesis and its Relation with Physical Exercise

Farioli-Vecchioli

Tirone

2015

BPL

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“…SAM MTases catalyze S N 2 methylation, using SAM as a methyl donor. Their functions are involved in many essential life processes, including gene expression (Katada & Sassone-Corsi, 2010;Min et al, 2003;Moore et al, 2013), protein modification (Falnes et al, 2016;Paik et al, 2014;Winter et al, 2018), neurotransmitter degradation (Akil et al, 2003;Männistö & Kaakkola, 1999;Witte & Flöel, 2012), and natural product synthesis (Liscombe et al, 2012;Ohashi et al, 2017Ohashi et al, , 2023. SAM MTases target various types of atoms, including carbon, nitrogen, oxygen, and sulfur (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

High‐throughput computational investigation of protein electrostatics and cavity for SAM‐dependent methyltransferases

Jurich

Yang

2023

Protein Science

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S‐adenosyl methionine (SAM)–dependent methyl transferases (MTases) are a ubiquitous class of enzymes catalyzing dozens of essential life processes. Despite targeting a large space of substrates with diverse intrinsic reactivity, SAM MTases have similar catalytic efficiency. While understanding of MTase mechanism has grown tremendously through the integration of structural characterization, kinetic assays, and multiscale simulations, it remains elusive how these enzymes have evolved to fit the diverse chemical needs of their respective substrates. In this work, we performed a high‐throughput molecular modeling analysis of 91 SAM MTases to better understand how their properties (i.e., electric field [EF] strength and active site volumes) help achieve similar catalytic efficiency toward substrates of different reactivity. We found that EF strengths have largely adjusted to make the target atom a better methyl acceptor. For MTases that target RNA/DNA and histone proteins, our results suggest that EF strength accommodates formal hybridization state and variation in cavity volume trends with diversity of substrate classes. Metal ions in SAM MTases contribute negatively to EF strength for methyl donation and enzyme scaffolds tend to offset these contributions.

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“…Their functions are involved in many essential life processes, including gene expression, [5][6][7] protein modification, [8][9][10] neurotransmitter degradation, [11][12][13] and natural product synthesis. [14][15][16] SAM MTases target various types of atoms, including carbon, nitrogen, oxygen and sulfur (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

High-Throughput Computational Investigation of Protein Electrostatics and Cavity for SAM-Dependent Methyltransferases

Jurich

Yang

2023

Preprint

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S-adenosyl methionine (SAM) -dependent methyl transferases (MTases) are aubiquitous class of enzymes catalyzing dozens of essential life processes. Despite targeting a largespace of substrates with diverse intrinsic reactivity, SAM MTases have similar catalytic efficiency.While understanding of MTase mechanism has grown tremendously through integration ofstructural characterization, kinetic assays, and multiscale simulations, it remains elusive regardinghow these enzymes have evolved to fit the diverse chemical needs of their respective substrates.In this work, we performed a high-throughput computational analysis of 91 SAM MTases to betterunderstand how the properties (i.e., electric field strength and active site volumes) of SAM MTaseshave been evolved to achieve similar catalytic efficiency towards substrates of different reactivity.We found that electric field strengths have largely evolved to make the target atom a better methylacceptor. For MTases that target RNA/DNA- and histone protein, our results suggest that electricfield strength accommodates hybridization state and variation in cavity volume trends withdiversity of substrate classes. Metal ions in SAM MTases contribute negatively to electric fieldstrength for methyl donation and enzyme scaffolds have evolved to offset these contributions.

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Protein Methylation and Interaction with the Antiproliferative Gene, BTG2^/TIS21/Pc3

Cited by 4 publications

References 102 publications

Control of the Cell Cycle in Adult Neurogenesis and its Relation with Physical Exercise

Control of the Cell Cycle in Adult Neurogenesis and its Relation with Physical Exercise

High‐throughput computational investigation of protein electrostatics and cavity for SAM‐dependent methyltransferases

High-Throughput Computational Investigation of Protein Electrostatics and Cavity for SAM-Dependent Methyltransferases

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Protein Methylation and Interaction with the Antiproliferative Gene, BTG2/TIS21/Pc3

Cited by 4 publications

References 102 publications

Control of the Cell Cycle in Adult Neurogenesis and its Relation with Physical Exercise

Control of the Cell Cycle in Adult Neurogenesis and its Relation with Physical Exercise

High‐throughput computational investigation of protein electrostatics and cavity for SAM‐dependent methyltransferases

High-Throughput Computational Investigation of Protein Electrostatics and Cavity for SAM-Dependent Methyltransferases

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Protein Methylation and Interaction with the Antiproliferative Gene, BTG2^/TIS21/Pc3