Protein Misfolding, Associated Diseases and Potential Therapeutic Routes: A Mini Review

Inhibition of Amyloid Beta Fibrilization by Small Organic Molecules: An Implication to Therapeutic Route of Alzheimer’s Disease

“…Journal of Advanced Scientific Research, 2021; 12 (3): Aug-2021 failure of chaperone action; wrong post-translational modifications, inappropriate trafficking of proteins and structural alteration caused by environmental stress factors [18,19]. Protein misfolding is currently linked to more than 25 diseases including well-known diseases such as cystic fibrosis, Alzheimer's disease, Parkinson's disease, as well as less familiar diseases such as Gaucher's disease, nephrogenic diabetes insipidus, and Creutzfeldt-Jakob disease [5,9]. Misfolded protein causes disease either by loss of function (LOF) or by gain of function (GOF) [20].…”

“…In this context, it is very much important to find ways to inhibit the aggregation process of amyloid beta and tau protein which can stop or postpone Alzheimer's disease. Many studies are taking place all over the world in which natural products, synthetically accessible small molecules and also peptides are being used as potential amyloid β inhibitors [5][6][7][8][9]. This article aims to review the in vitro and in vivo studies with small and simple organic molecules which show ability to suppress or postponed fibrillation process of amyloid β protein and thus can be very important in the path of drug discovery of Alzheimer's disease.…”