Protein Nanomechanics

Abstract

For a comprehensive understanding of protein function and dynamics, it is crucial to study their mechanical properties [...]

Viscoelasticity of single folded proteins using dynamic atomic force microscopy

“…147,148 Particularly encouraging is the result which suggests that a coarse-grained model for simulation qualitatively agrees with experiments as well as detailed simulations. 149 Many AI-based approaches successfully predict the dynamics and flexibility of sub-structures 150 and are computationally cheaper compared to steered MD. 151 With the availability of bioconjugation strategies to link DNA handles to proteins, 152 direct measurement of elastic and viscous components using measurements such as presented in ref.…”