2019
DOI: 10.1002/smll.201970010
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Protein Nanoparticles: A Novel Self‐Assembled Mitochondria‐Targeting Protein Nanoparticle Acting as Theranostic Platform for Cancer (Small 2/2019)

Abstract: In article number https://doi.org/10.1002/smll.201803428, Jian Lin and co‐workers report the discovery of a novel self‐assembled metal protein nanoparticle, designated GST‐MT‐3, which targets the mitochondria of cancer cells within 30 min in vitro and rapidly accumulates in tumors within 1 h in vivo. The little men carrying the bombs represent GST‐MT3 protein nanoparticles loading the cobalt ions. Through the blood vessels they accumulate in tumor regions rapidly. Meanwhile, they target the mitochondria and in… Show more

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“…Homobifunctional Nhydroxysuccinimide (NHS)-ester functionalized polyethylene glycol (PEG) based macromers were incorporated into the jetting solution with the protein. [91] Specifically, 2 kDa O,O′bis[2-(N-succinimidyl-succinylamino)ethyl]polyethylene glycol (PEG-NHS) and 4,7,10, 13,16,19,22,25,32,35,38,41,44,47,50,53hexadecaoxa-28,29-dithiahexapentacontanedioic acid di-Nsuccinimidyl ester (PEG-NHS-S) were used that reacted with the proteins' amine groups. [91] The reaction was completed after incubating the solidified PNPs at 37 °C for seven days.…”
Section: Electohydrodynamic Co-jettingmentioning
confidence: 99%
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“…Homobifunctional Nhydroxysuccinimide (NHS)-ester functionalized polyethylene glycol (PEG) based macromers were incorporated into the jetting solution with the protein. [91] Specifically, 2 kDa O,O′bis[2-(N-succinimidyl-succinylamino)ethyl]polyethylene glycol (PEG-NHS) and 4,7,10, 13,16,19,22,25,32,35,38,41,44,47,50,53hexadecaoxa-28,29-dithiahexapentacontanedioic acid di-Nsuccinimidyl ester (PEG-NHS-S) were used that reacted with the proteins' amine groups. [91] The reaction was completed after incubating the solidified PNPs at 37 °C for seven days.…”
Section: Electohydrodynamic Co-jettingmentioning
confidence: 99%
“…These engineered PNPs can be produced from a various sources of proteins (from plant to serum) and has been exploited in various applications ranging from biotechnology to food industries ( Table 1 ). [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ]…”
Section: Introductionmentioning
confidence: 99%
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