Protein oxidation inhibits NO-mediated signaling pathway for synaptic plasticity

Kakizawa, Sho; Shibazaki, Masahiko; Mori, Nozomu

doi:10.1016/j.neurobiolaging.2010.04.016

Cited by 17 publications

(14 citation statements)

References 68 publications

(92 reference statements)

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“…The irreversible carbonylation of proteins may thus prevent reversible PTMs, such as S-nitrosylation and phosphorylation, from occurring or vice versa. This is supported by observations in animals and the effects of NO and HCN in alleviating protein oxidation in seeds [ 11 , 129 , 180 , 210 , 211 ]. Besides Cys, carbonylation at Lys residues influences the effects of acetylation, methylation, mono- and polyubiquitination, and SUMOylation of proteins.…”

Section: Crosstalk Between Carbonylation and Other Ptmssupporting

confidence: 73%

Protein Carbonylation: Emerging Roles in Plant Redox Biology and Future Prospects

Tola

Jaballi

Missihoun

2021

Plants

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Plants are sessile in nature and they perceive and react to environmental stresses such as abiotic and biotic factors. These induce a change in the cellular homeostasis of reactive oxygen species (ROS). ROS are known to react with cellular components, including DNA, lipids, and proteins, and to interfere with hormone signaling via several post-translational modifications (PTMs). Protein carbonylation (PC) is a non-enzymatic and irreversible PTM induced by ROS. The non-enzymatic feature of the carbonylation reaction has slowed the efforts to identify functions regulated by PC in plants. Yet, in prokaryotic and animal cells, studies have shown the relevance of protein carbonylation as a signal transduction mechanism in physiological processes including hydrogen peroxide sensing, cell proliferation and survival, ferroptosis, and antioxidant response. In this review, we provide a detailed update on the most recent findings pertaining to the role of PC and its implications in various physiological processes in plants. By leveraging the progress made in bacteria and animals, we highlight the main challenges in studying the impacts of carbonylation on protein functions in vivo and the knowledge gap in plants. Inspired by the success stories in animal sciences, we then suggest a few approaches that could be undertaken to overcome these challenges in plant research. Overall, this review describes the state of protein carbonylation research in plants and proposes new research avenues on the link between protein carbonylation and plant redox biology.

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Section: Crosstalk Between Carbonylation and Other Ptmssupporting

confidence: 73%

Protein Carbonylation: Emerging Roles in Plant Redox Biology and Future Prospects

Tola

Jaballi

Missihoun

2021

Plants

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“…In cerebellar slices from young mice, LTP at Purkinje cells is blocked after incubation with oxidizing agents or thiol blocker. 365 ROS blocks the LTP through the inhibition of the NO-induced protein S-nitrosylation, which is a fundamental step for the expression of synaptic potentiation. 365…”

Section: Neural Structure Effects Of Ros Mechanismsmentioning

confidence: 99%

Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity

2016

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In the mammalian central nervous system, reactive oxygen species (ROS) generation is counterbalanced by antioxidant defenses. When large amounts of ROS accumulate, antioxidant mechanisms become overwhelmed and oxidative cellular stress may occur. Therefore, ROS are typically characterized as toxic molecules, oxidizing membrane lipids, changing the conformation of proteins, damaging nucleic acids, and causing deficits in synaptic plasticity. High ROS concentrations are associated with a decline in cognitive functions, as observed in some neurodegenerative disorders and age-dependent decay of neuroplasticity. Nevertheless, controlled ROS production provides the optimal redox state for the activation of transductional pathways involved in synaptic changes. Since ROS may regulate neuronal activity and elicit negative effects at the same time, the distinction between beneficial and deleterious consequences is unclear. In this regard, this review assesses current research and describes the main sources of ROS in neurons, specifying their involvement in synaptic plasticity and distinguishing between physiological and pathological processes implicated.

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“…Thus, ROS and NO competitively target Cys residues to exert their biological action, and therefore it is likely that a tight link between oxidation and nitrosylation exists. Recently, protein oxidation was shown to impair synaptic plasticity through the inhibition of S ‐nitrosylation in a competitive manner . Similarly, evidence has accumulated demonstrating the occurrence of a biological connection between protein oxidation and S ‐nitrosylation in plants.…”

Section: Evidence For Crosstalk Between Ros‐based Carbonylation and Rmentioning

confidence: 99%

Interplay between protein carbonylation and nitrosylation in plants

et al. 2012

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ROS and reactive nitrogen species (RNS) are key regulators of redox homeostasis in living organisms including plants. As control of redox homeostasis plays a central function in plant biology, redox proteomics could help in characterizing the potential roles played by ROS/RNS-induced posttranslational modification in plant cells. In this review, we focus on two posttranslational modifications: protein carbonylation (a marker of protein oxidation) and protein S-nitrosylation, both of which having recently emerged as important regulatory mechanisms during numerous fundamental biological processes. Here, we describe the recent progress in proteomic analysis of carbonylated and nitrosylated proteins and highlight the achievements made in understanding the physiological basis of these oxy/nitro modifications in plants. In addition, we document the existence of a relationship between ROS-based carbonylation and RNS-based nitrosylation thus supporting the finding that crosstalk between cellular signaling stress pathways induced by ROS and RNS could be mediated by specific protein modifications.

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Protein oxidation inhibits NO-mediated signaling pathway for synaptic plasticity

Cited by 17 publications

References 68 publications

Protein Carbonylation: Emerging Roles in Plant Redox Biology and Future Prospects

Protein Carbonylation: Emerging Roles in Plant Redox Biology and Future Prospects

Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity

Interplay between protein carbonylation and nitrosylation in plants

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