Protein/Peptide Drug Delivery Systems

Deb, Pran Kishore; Al-Attraqchi, Omar; Chandrasekaran, Balakumar; Paradkar, Anant; Tekade, Rakesh K.

doi:10.1016/b978-0-12-817909-3.00016-9

Cited by 29 publications

(21 citation statements)

References 76 publications

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“…In these systems, water-soluble drugs are encapsulated in the aqueouse core which consists of hydrophilic parts of the phospholipids, and the insoluble agents are entrapped in the hydrophobic domain which contains lipid part of the phospholipids bilayer. 73,74 Nanoliposomes have different structural sizes and shapes based on environmental circumstances, their constituents, and their production techniques. 75 Liposomes can be categorized into five types based on their diameter: 1) multilamellar vesicles (MLV)-0.5-5 nm with five to twenty lipid bilayers, 2) small unilamellar one lipid bilayer vesicles (SUV)-20-200 nm, 3) largeunilamellar vesicles with one lipid bilayer (LUV)-200nm, 4) giant unilamellar vesicles with one lipid bilayer (GUV)-1nm, and 5) multi vesicular vesicles (MVV) with multi lipid bilayer-1 nm.…”

Section: Nanoliposomes 461 Characteristics Of Nanoliposomesmentioning

confidence: 99%

Encapsulation of Vitamins Using Nanoliposome: Recent Advances and Perspectives

et al. 2021

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Nowadays the importance of vitamins is clear for everyone. However, many patients are suffering from insufficient intake of vitamins. Incomplete intake of different vitamins from food sources due to their destruction during food processing or decrease in their bioavailability when mixing with other food materials, are factors resulting in vitamin deficiency in the body. Therefore, various lipid based nanocarriers such as nanoliposomes were developed to increase the bioavailability of bioactive compounds. Since the function of nanoliposomes containing vitamins on the body has a direct relationship with the quality of produced nanoliposomes, this review study was planned to investigate the several aspects of liposomal characteristics such as size, polydispersity index, zeta potential, and encapsulation efficiency on the quality of synthesized vitamin-loaded nanoliposomes.

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Section: Nanoliposomes 461 Characteristics Of Nanoliposomesmentioning

confidence: 99%

Encapsulation of Vitamins Using Nanoliposome: Recent Advances and Perspectives

et al. 2021

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“…These small molecular immunosuppressive drugs are thus able to cross the BBB easily and are useful in treating brain and spinal cord injuries [53]. Peptidomimetics are small protein-like chains intended to mimic peptides [64]. There are chemical modification methods that involve modifying the peptide structure to improve pharmacokinetic properties while simultaneously retaining a specific amino acid part(s) responsible for activity [64].…”

Section: Drug Delivery Across the Bbbmentioning

confidence: 99%

“…Peptidomimetics are small protein-like chains intended to mimic peptides [64]. There are chemical modification methods that involve modifying the peptide structure to improve pharmacokinetic properties while simultaneously retaining a specific amino acid part(s) responsible for activity [64]. The absorption of polar drugs can be achieved by increasing their hydrophobicity, however, the volume of distribution of the drug within the body will also increase [53,65].…”

Section: Drug Delivery Across the Bbbmentioning

confidence: 99%

Permeation Challenges of Drugs for Treatment of Neurological Tuberculosis and HIV and the Application of Magneto-Electric Nanoparticle Drug Delivery Systems

et al. 2021

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The anatomical structure of the brain at the blood–brain barrier (BBB) creates a limitation for the movement of drugs into the central nervous system (CNS). Drug delivery facilitated by magneto-electric nanoparticles (MENs) is a relatively new non-invasive approach for the delivery of drugs into the CNS. These nanoparticles (NPs) can create localized transient changes in the permeability of the cells of the BBB by inducing electroporation. MENs can be applied to deliver antiretrovirals and antibiotics towards the treatment of human immunodeficiency virus (HIV) and tuberculosis (TB) infections in the CNS. This review focuses on the drug permeation challenges and reviews the application of MENs for drug delivery for these diseases. We conclude that MENs are promising systems for effective CNS drug delivery and treatment for these diseases, however, further pre-clinical and clinical studies are required to achieve translation of this approach to the clinic.

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“…Microspheres can form a system of continuous drug release; they also protect drugs against enzyme degradation [ 117 ]. They can be obtained by spray drying, double emulsification, or complexation with other substances [ 131 ]. Microspheres become hydrated after absorbing water from epithelial cells, when the cells are reversibly dehydrated and in this way, promote junction opening and drug absorption [ 124 , 132 ].…”

Section: Chitosan-based Formulations For Intranasal Administrationmentioning

confidence: 99%

New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

Popescu

Ghica

Dinu-Pîrvu

et al. 2020

IJMS

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In an attempt to develop drug delivery systems that bypass the blood–brain barrier (BBB) and prevent liver and intestinal degradation, it was concluded that nasal medication meets these criteria and can be used for drugs that have these drawbacks. The aim of this review is to present the influence of the properties of chitosan and its derivatives (mucoadhesion, permeability enhancement, surface tension, and zeta potential) on the development of suitable nasal drug delivery systems and on the nasal bioavailability of various active pharmaceutical ingredients. Interactions between chitosan and proteins, lipids, antigens, and other molecules lead to complexes that have their own applications or to changing characteristics of the substances involved in the bond (conformational changes, increased stability or solubility, etc.). Chitosan and its derivatives have their own actions (antibacterial, antifungal, immunostimulant, antioxidant, etc.) and can be used as such or in combination with other molecules from the same class to achieve a synergistic effect. The applicability of the properties is set out in the second part of the paper, where nasal formulations based on chitosan are described (vaccines, hydrogels, nanoparticles, nanostructured lipid carriers (NLC), powders, emulsions, etc.).

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Protein/Peptide Drug Delivery Systems

Cited by 29 publications

References 76 publications

Encapsulation of Vitamins Using Nanoliposome: Recent Advances and Perspectives

Encapsulation of Vitamins Using Nanoliposome: Recent Advances and Perspectives

Permeation Challenges of Drugs for Treatment of Neurological Tuberculosis and HIV and the Application of Magneto-Electric Nanoparticle Drug Delivery Systems

New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

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