Protein persulfidation: Rewiring the hydrogen sulfide signaling in cell stress response

He, Bo; Zhang, Zhe; Zhao, Haitao; Duan, Xirui; Wang, Yu; Cao, Jiangjun; Li, Lei; He, Kai; Nice, Edouard C.; He, Weifeng; Gao, Wei; Shen, Zhisen

doi:10.1016/j.bcp.2023.115444

Cited by 21 publications

(11 citation statements)

References 328 publications

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“…Indeed, H 2 S’s outcomes are highly concentration-dependent [ 81 , 82 ]. Physiological concentrations of H 2 S are generally associated with cytoprotection against oxidative stress [ 83 ]. However, elevated H 2 S levels can contribute to oxidative stress, especially under pathophysiological conditions [ 10 ].…”

Section: Resultsmentioning

confidence: 99%

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Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Munteanu,

Turnea,

Rotariu

2023

Antioxidants

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Hydrogen sulfide (H2S), traditionally recognized as a toxic gas, has emerged as a critical regulator in many biological processes, including oxidative stress and cellular homeostasis. This review presents an exhaustive overview of the current understanding of H2S and its multifaceted role in mammalian cellular functioning and oxidative stress management. We delve into the biological sources and function of H2S, mechanisms underlying oxidative stress and cellular homeostasis, and the intricate relationships between these processes. We explore evidence from recent experimental and clinical studies, unraveling the intricate biochemical and molecular mechanisms dictating H2S’s roles in modulating oxidative stress responses and maintaining cellular homeostasis. The clinical implications and therapeutic potential of H2S in conditions characterized by oxidative stress dysregulation and disrupted homeostasis are discussed, highlighting the emerging significance of H2S in health and disease. Finally, this review underscores current challenges, controversies, and future directions in the field, emphasizing the need for further research to harness H2S’s potential as a therapeutic agent for diseases associated with oxidative stress and homeostatic imbalance. Through this review, we aim to emphasize H2S’s pivotal role in cellular function, encouraging further exploration into this burgeoning area of research.

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Section: Resultsmentioning

confidence: 99%

“…It can modulate the activity of a wide range of proteins through a process known as persulfidation, wherein a sulfur atom is added to the protein, affecting its function. This post-translational modification can impact various signaling pathways and has been linked to autophagy, inflammation, and cellular stress response [ 13 , 83 ].…”

Section: Resultsmentioning

confidence: 99%

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Munteanu,

Turnea,

Rotariu

2023

Antioxidants

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“…In endothelial cells, lanthionine (a prospective uremic toxin and a byproduct of H 2 S biosynthesis) hampers H 2 S release; reduces protein content and glutathionylation of the transsulfuration enzyme CBS; modifies the expression of miR-200c, miR-423, and vascular endothelial growth factor; and, most importantly in this context, increases intracellular Ca 2+ levels [ 42 ]. Protein persulfidation, a posttranslational modification of cysteine residues to persulfides caused by H 2 S, is an important mechanism of H 2 S-mediated signaling pathways [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Hydrogen Sulfide on Essential Functions of Polymorphonuclear Leukocytes

Farahat

Kherkheulidze

Nopp

et al. 2023

Toxins

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Impaired polymorphonuclear leukocyte (PMNL) functions contribute to increased infections and cardiovascular diseases in chronic kidney disease (CKD). Uremic toxins reduce hydrogen sulfide (H2S) levels and the anti-oxidant and anti-inflammatory effects of H2S. Its biosynthesis occurs as a side process of transsulfuration and in the disposal of adenosylhomocysteine, a transmethylation inhibitor and proposed uremic toxin. PMNL chemotaxis was measured by the under-agarose method, phagocytosis, and oxidative burst by flow cytometry in whole blood and apoptosis by determining DNA content by flow cytometry and morphological features by fluorescence microscopy. Sodium hydrogen sulfide (NaHS), diallyl trisulphide (DATS) and diallyl disulphide (DADS), cysteine, and GYY4137 were used as H2S-producing substances. Increased H2S concentrations did not affect chemotaxis and phagocytosis. NaHS primed PMNL oxidative burst activated by phorbol 12-myristate 13-acetate (PMA) or E. coli. Both DATS and cysteine significantly decreased E. coli-activated oxidative burst but had no effect on PMA stimulation. While NaHS, DADS, and cysteine attenuated PMNL apoptosis, GYY4137 decreased their viability. Experiments with signal transduction inhibitors suggest that the intrinsic apoptosis pathway is mainly involved in GYY4137-induced PMNL apoptosis and that GYY4137 and cysteine target signaling downstream of phosphoinositide 3-kinase.

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“…54,55 as well as acetylation, ubiquitinylation, and persulfidation. 56 Top-down proteomics also has been used. Protein−protein interaction studies provide insight into normal and disease-related biological pathways.…”

Section: Cancersmentioning

confidence: 99%

“…Human blood proteoform atlases from the Human Protein Atlas are identifying biomarkers for development of personalized/precision medicine. PTM analyses are a significant interest, with phosphorylation and glycosylation most widely studied, , as well as acetylation, ubiquitinylation, and persulfidation . Top-down proteomics also has been used.…”

Section: Biology and Disease-driven Hppmentioning

confidence: 99%

The 2023 Report on the Proteome from the HUPO Human Proteome Project

Omenn,

Lane,

Overall

et al. 2024

J. Proteome Res.

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Since 2010, the Human Proteome Project (HPP), the flagship initiative of the Human Proteome Organization (HUPO), has pursued two goals: (1) to credibly identify the protein parts list and (2) to make proteomics an integral part of multiomics studies of human health and disease. The HPP relies on international collaboration, data sharing, standardized reanalysis of MS data sets by PeptideAtlas and MassIVE-KB using HPP Guidelines for quality assurance, integration and curation of MS and non-MS protein data by neXtProt, plus extensive use of antibody profiling carried out by the Human Protein Atlas. According to the neXtProt release 2023-04-18, protein expression has now been credibly detected (PE1) for 18,397 of the 19,778 neXtProt predicted proteins coded in the human genome (93%). Of these PE1 proteins, 17,453 were detected with mass spectrometry (MS) in accordance with HPP Guidelines and 944 by a variety of non-MS methods. The number of neXtProt PE2, PE3, and PE4 missing proteins now stands at 1381. Achieving the unambiguous identification of 93% of predicted proteins encoded from across all chromosomes represents remarkable experimental progress on the Human Proteome parts list. Meanwhile, there are several categories of predicted proteins that have proved resistant to detection regardless of protein-based methods used. Additionally there are some PE1–4 proteins that probably should be reclassified to PE5, specifically 21 LINC entries and ∼30 HERV entries; these are being addressed in the present year. Applying proteomics in a wide array of biological and clinical studies ensures integration with other omics platforms as reported by the Biology and Disease-driven HPP teams and the antibody and pathology resource pillars. Current progress has positioned the HPP to transition to its Grand Challenge Project focused on determining the primary function(s) of every protein itself and in networks and pathways within the context of human health and disease.

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Protein persulfidation: Rewiring the hydrogen sulfide signaling in cell stress response

Cited by 21 publications

References 328 publications

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Effect of Hydrogen Sulfide on Essential Functions of Polymorphonuclear Leukocytes

The 2023 Report on the Proteome from the HUPO Human Proteome Project

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