Protein phosphatase 2A regulatory subunits affecting plant innate immunity, energy metabolism, and flowering time – joint functions among B'η subfamily members

Kataya, Amr R.A.; Heidari, Behzad Shiroud; Lillo, Cathrine

doi:10.1080/15592324.2015.1026024

Cited by 25 publications

(26 citation statements)

References 21 publications

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“…A mutant deficient in B′𝜃 displays increased resistance toward P. syringae pv. tomato ( Kataya et al, 2015a ). B′𝜃 co-localizes with PP2A-C2, PP2A-C5, and PP2A-A2 in peroxisomes, where its positive impact maintains β-oxidation of fatty acids and protoauxins ( Kataya et al, 2015b ).…”

Section: Pp2a As a Regulator Of Intracellular Signaling Network And mentioning

confidence: 99%

Protein Phosphatase 2A in the Regulatory Network Underlying Biotic Stress Resistance in Plants

et al. 2016

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Biotic stress factors pose a major threat to plant health and can significantly deteriorate plant productivity by impairing the physiological functions of the plant. To combat the wide range of pathogens and insect herbivores, plants deploy converging signaling pathways, where counteracting activities of protein kinases and phosphatases form a basic mechanism for determining appropriate defensive measures. Recent studies have identified Protein Phosphatase 2A (PP2A) as a crucial component that controls pathogenesis responses in various plant species. Genetic, proteomic and metabolomic approaches have underscored the versatile nature of PP2A, which contributes to the regulation of receptor signaling, organellar signaling, gene expression, metabolic pathways, and cell death, all of which essentially impact plant immunity. Associated with this, various PP2A subunits mediate post-translational regulation of metabolic enzymes and signaling components. Here we provide an overview of protein kinase/phosphatase functions in plant immunity signaling, and position the multifaceted functions of PP2A in the tightly inter-connected regulatory network that controls the perception, signaling and responding to biotic stress agents in plants.

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Section: Pp2a As a Regulator Of Intracellular Signaling Network And mentioning

confidence: 99%

Protein Phosphatase 2A in the Regulatory Network Underlying Biotic Stress Resistance in Plants

et al. 2016

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“…PP2A is also implicated in abscisic acid (Kwak et al, ; Pernas, Garcia‐Casado, Rojo, Solano, & Sanchez‐Serrano, ; Waadt et al, ) and ethylene signalling (Muday et al, ; Skottke, Yoon, Kieber, & DeLong, ). Furthermore, PP2A dephosphorylates enzymes in primary metabolism, that is, key enzymes in nitrogen assimilation, sugar, and lipid metabolism (Douglas, Pigaglio, Ferrer, Halfords, & MacKintosh, ; Huber, MacKintosh, & Kaiser, ; Kataya, Heidari, & Lillo, ). Iron nutrition also involves PP2A, where expression of key players of iron homeostasis (FIT1, FRO2, and FER1) is promoted by PP2A (Arnaud et al, ; Chen et al, ).…”

Section: Introductionmentioning

confidence: 99%

Methylation of protein phosphatase 2A—Influence of regulators and environmental stress factors

Creighton

Kołton

Kataya

et al. 2017

Plant Cell & Environment

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Protein phosphatase 2A catalytic subunit (PP2A-C) has a terminal leucine subjected to methylation, a regulatory mechanism conserved from yeast to mammals and plants. Two enzymes, LCMT1 and PME1, methylate and demethylate PP2A-C, respectively. The physiological importance of these posttranslational modifications is still enigmatic. We investigated these processes in Arabidopsis thaliana by mutant phenotyping, by global expression analysis, and by monitoring methylation status of PP2A-C under different environmental conditions. The lcmt1 mutant, possessing essentially only unmethylated PP2A-C, had less dense rosettes, and earlier flowering than wild type (WT). The pme1 mutant, with 30% reduction in unmethylated PP2A-C, was phenotypically comparable with WT. Approximately 200 overlapping genes were twofold upregulated, and 200 overlapping genes were twofold downregulated in both lcmt1 and pme1 relative to WT. Differences between the 2 mutants were also striking; 97 genes were twofold upregulated in pme1 compared with lcmt1, indicating that PME1 acts as a negative regulator for these genes. Analysis of enriched GO terms revealed categories of both abiotic and biotic stress genes. Furthermore, methylation status of PP2A-C was influenced by environmental stress, especially by hypoxia and salt stress, which led to increased levels of unmethylated PP2A-C, and highlights the importance of PP2A-C methylation/demethylation in environmental responses.

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“…B'ζ may be involved in energy metabolism as the b'ζ knockout seedlings showed retarded hypocotyl growth on sucrose-free medium. Also, it is highly expressed during senescence alongwith most of the fatty acid degradation enzymes indicating that both B'θ and B'ζ are involved in energy metabolism [78].…”

Section: Pp2a Phosphatases and The Rna-centered Approachesmentioning

confidence: 99%

“…Similar to other B'η members, PP2A-B'θ is involved in negative regulation of plant innate immunity as observed by the decreased proliferation of the virulent Pseudomonas syringae in the b'θ mutants in comparison with the wild type plants. The b'θ mutants were found to show delayed flowering phenotype supported by high expression of the FLOW-ERING LOCUS C, FLC [78]. PP2A acts both as a positive and negative regulator of flowering with PP2A-B55 acting as a negative regulator whereas PP2A-B'γ acts as a positive regulator.…”

Section: Pp2a Phosphatases and The Rna-centered Approachesmentioning

confidence: 99%

PP2A Phosphatases Take a Giant Leap in the Post-Genomics Era

Bheri

Pandey

2019

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Background: Protein phosphorylation is an important reversible post-translational modification, which regulates a number of critical cellular processes. Phosphatases and kinases work in a concerted manner to act as a “molecular switch” that turns-on or - off the regulatory processes driving the growth and development under normal circumstances, as well as responses to multiple stresses in plant system. The era of functional genomics has ushered huge amounts of information to the framework of plant systems. The comprehension of who’s who in the signaling pathways is becoming clearer and the investigations challenging the conventional functions of signaling components are on a rise. Protein phosphatases have emerged as key regulators in the signaling cascades. PP2A phosphatases due to their diverse holoenzyme compositions are difficult to comprehend. Conclusion: In this review, we highlight the functional versatility of PP2A members, deciphered through the advances in the post-genomic era.

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Protein phosphatase 2A regulatory subunits affecting plant innate immunity, energy metabolism, and flowering time – joint functions among B'η subfamily members

Cited by 25 publications

References 21 publications

Protein Phosphatase 2A in the Regulatory Network Underlying Biotic Stress Resistance in Plants

Protein Phosphatase 2A in the Regulatory Network Underlying Biotic Stress Resistance in Plants

Methylation of protein phosphatase 2A—Influence of regulators and environmental stress factors

PP2A Phosphatases Take a Giant Leap in the Post-Genomics Era

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