Protein-polysaccharide nanoconjugates: Potential tools for delivery of plant-derived nutraceuticals

Paliya, Balwant Singh; Sharma, Vivek; Sharma, Minaxi; Diwan, Deepti; Nguyen, Quang Dung; Aminabhavi, Tejraj M.; Rajauria, Gaurav; Singh, Brahma N.; Gupta, Vijai Kumar

doi:10.1016/j.foodchem.2023.136709

Cited by 30 publications

(7 citation statements)

References 104 publications

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“…Thus, with regard to the development of new drug-delivery systems, the hybrid pectin-vaterite microparticles demonstrated a number of valuable properties. Vaterite and pectin are natural materials, with both being biocompatible and biodegradable [30][31][32][33]. Moreover, they are pH-sensitive due to the vaterite matrix [34]; thus, the pH-sensitivity of the drug-delivery system could play an important role in the colon of patients with inflammatory bowel disease (IBD), where the pH is lower than in a normal colon (up to 2.3 vs. 6.8) [35].…”

Section: Discussionmentioning

confidence: 99%

Incorporation of Pectin into Vaterite Microparticles Prevented Effects of Adsorbed Mucin on Neutrophil Activation

Mikhalchik,

Maltseva,

Firova

et al. 2023

IJMS

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The application of vaterite microparticles for mucosal delivery depends on their interaction with mucin and immune cells. As we have shown previously, the binding of mucin onto particles enhances the generation of reactive oxygen species by neutrophils. The attenuation of the pro-oxidant effect of the bound mucin through the modification of vaterite could improve its biocompatibility. Hybrid microparticles composed of vaterite and pectin (CCP) were prepared using co-precipitation. In comparison with vaterite (CC), they had a smaller diameter and pores, a greater surface area, and a negative zeta-potential. We aimed to study the cytotoxicity and mucin-dependent neutrophil-activating effect of CCP microparticles. The incorporated pectin did not influence the neutrophil damage according to a lactate dehydrogenase test. The difference in the CC- and CCP-elicited luminol or lucigenin chemiluminescence of neutrophils was insignificant, with no direct pro- or antioxidant effects from the incorporated pectin. Unlike soluble pectin, the CCP particles were ineffective at scavenging radicals in an ABAP–luminol test. The fluorescence of SYTOX Green demonstrated a CCP-stimulated formation of neutrophil extracellular traps (NETs). The pre-treatment of CC and CCP with mucin resulted in a 2.5-times-higher CL response of neutrophils to the CC-mucin than to the CCP-mucin. Thus, the incorporation of pectin into vaterite microspheres enabled an antioxidant effect to be reached when the neutrophils were activated by mucin-treated microparticles, presumably via exposed ligands.

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Section: Discussionmentioning

confidence: 99%

Incorporation of Pectin into Vaterite Microparticles Prevented Effects of Adsorbed Mucin on Neutrophil Activation

Mikhalchik,

Maltseva,

Firova

et al. 2023

IJMS

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“…These nanoformulations involve incorporating drugs or therapeutic agents into polysaccharide-based nanocarriers to enhance drug stability, solubility, and targeted delivery to specific tissues or cells. Various polysaccharides, already mentioned above, such as chitosan, alginate, hyaluronic acid, cellulose, dextran, and others, have been utilized in the development of nanoformulations for drug delivery purposes and with antioxidative properties [97][98][99][100][101]. In their detailed review, Mizrahy and Peer thoroughly examined the primary mechanisms generally involved in the synthesis of polysaccharide nanoparticles [102].…”

Section: Different Formulationsmentioning

confidence: 99%

A Review of Recent Developments in Biopolymer Nano-Based Drug Delivery Systems with Antioxidative Properties: Insights into the Last Five Years

Stevanović,

Filipović

2024

Pharmaceutics

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In recent years, biopolymer-based nano-drug delivery systems with antioxidative properties have gained significant attention in the field of pharmaceutical research. These systems offer promising strategies for targeted and controlled drug delivery while also providing antioxidant effects that can mitigate oxidative stress-related diseases. Generally, the healthcare landscape is constantly evolving, necessitating the continual development of innovative therapeutic approaches and drug delivery systems (DDSs). DDSs play a pivotal role in enhancing treatment efficacy, minimizing adverse effects, and optimizing patient compliance. Among these, nanotechnology-driven delivery approaches have garnered significant attention due to their unique properties, such as improved solubility, controlled release, and targeted delivery. Nanomaterials, including nanoparticles, nanocapsules, nanotubes, etc., offer versatile platforms for drug delivery and tissue engineering applications. Additionally, biopolymer-based DDSs hold immense promise, leveraging natural or synthetic biopolymers to encapsulate drugs and enable targeted and controlled release. These systems offer numerous advantages, including biocompatibility, biodegradability, and low immunogenicity. The utilization of polysaccharides, polynucleotides, proteins, and polyesters as biopolymer matrices further enhances the versatility and applicability of DDSs. Moreover, substances with antioxidative properties have emerged as key players in combating oxidative stress-related diseases, offering protection against cellular damage and chronic illnesses. The development of biopolymer-based nanoformulations with antioxidative properties represents a burgeoning research area, with a substantial increase in publications in recent years. This review provides a comprehensive overview of the recent developments within this area over the past five years. It discusses various biopolymer materials, fabrication techniques, stabilizers, factors influencing degradation, and drug release. Additionally, it highlights emerging trends, challenges, and prospects in this rapidly evolving field.

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“…Furthermore, the emulsion gels prevent the active substances from interacting with other compounds in the gastrointestinal tract. Soy protein‐based emulsion gels have been widely reported to deliver and encapsulate nutraceuticals and bioactive substances (Li et al., 2023; Paliya et al., 2023).…”

Section: Application Of Soy Protein Gelmentioning

confidence: 99%

Recent advance in modification strategies and applications of soy protein gel properties

Liang,

Chen,

Fang

et al. 2023

Comp Rev Food Sci Food Safe

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Soy protein gel can be developed into a variety of products, ranging from traditional food (e.g., tofu) to newly developed food (e.g., soy yogurt and meat analog). So far, efforts are still needed to be made on modifying the gel properties of soy protein for improving its sensory properties as animal protein‐based food substitutes. Furthermore, there is always a need to regulate its gel properties for designing novel and tailored products of soy protein gels due to the fast‐growing plant protein‐based product market. This review gave an emphasis on the latest modification strategies and applications of gel properties of soy protein. The modifying methods of soy protein gel properties were reviewed from an aspect of composition or processing. Compositional modification included changing protein composition and gelling conditions and using additives, whereas processing strategies can be achieved through physical, chemical, and enzymatic treatments. Several compositional modification and processing strategies have been both proven to alter the gel properties of soy protein effectively. So far, soy protein gel has been applied in the field of food and biomedicine. In the future, more mechanistic studies on the modification methods are still needed to facilitate the full application of soy protein gel.

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Protein-polysaccharide nanoconjugates: Potential tools for delivery of plant-derived nutraceuticals

Cited by 30 publications

References 104 publications

Incorporation of Pectin into Vaterite Microparticles Prevented Effects of Adsorbed Mucin on Neutrophil Activation

Incorporation of Pectin into Vaterite Microparticles Prevented Effects of Adsorbed Mucin on Neutrophil Activation

A Review of Recent Developments in Biopolymer Nano-Based Drug Delivery Systems with Antioxidative Properties: Insights into the Last Five Years

Recent advance in modification strategies and applications of soy protein gel properties

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