Traditional Camis cheese may be an interesting dairy product with potential bioactivities and postconsumption health effects. The aim of this study was to evaluate the antimicrobial and antioxidant activity of Camis cheeses produced by two different traditional methods, differing in heat processing of the milk and boiling the curd, and to reveal the changes that occur depending on 90 days of ripening time. For this purpose, physicochemical and sensory analyses were performed, and antimicrobial and antioxidant activity analyses of the water‐soluble extracts (WSEs) of Camis cheeses (B1 and B2) were conducted. WSEs of both cheeses (800 μL mL−1) had remarkable antimicrobial effects on Escherichia coli (E. coli) and Staphylococcus aureus (Staph. aureus), with a higher inhibitory effect on E. coli. The Trolox equivalent antioxidant capacity (TEAC) values (0.12–2.24 μM Trolox) and % inhibition rates as 2,2‐diphenyl‐1‐picrylhydrazil (DPPH) radical scavenging activity (8.54–26.34%) of the cheeses indicate limited antioxidant activity. The curd boiling process was found to have a favorable effect on the antimicrobial and antioxidant activity of the Camis cheeses. However, the panelists' perceptions of flavor, texture, and total acceptability did not align with this positive outcome. The results of this study reveal that the consumption of traditional Camis cheese and its extracts or the use of purified bioactive peptides in functional food products may constitute an important alternative in terms of eliminating the negative effects encountered with the use of synthetic antimicrobial and antioxidant components to provide the desired health effect from natural sources.