Protein Profiling of Oreochromis spp. Epidermal Mucus Subsequent to Challenge of Common Freshwater Bacteria

Mohd, F Mohd Fadhil

doi:10.30954/0974-1712.04.2020.16

Cited by 1 publication

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“…Recently, we have shown that EM from freshwater healthy fish, inhibited the climatic condition of Pakistan, has bactericidal role against bacteria (Ali et al, 2023). The EM of bacterial-challenged fish showed interesting activity against fish as well as human bacterial pathogens (Mohd et al, 2020;Subramanian et al, 2007); hence, we report the bactericidal role of EM from five freshwater Cyprinid fish after treatment with A. hydrophila. This study may provide useful understanding of skin mucus role in innate immunity and their interaction with bacteria (Blanc et al, 2022;Cho et al, 2022), which could help in the development of bactericidal agents for therapeutic applications.…”

Section: Introductionmentioning

confidence: 78%

Bactericidal role of epidermal mucus of freshwater fish treated withAeromonas hydrophila

Ali,

Shah,

Rauf

et al. 2023

Journal of Fish Diseases

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This study explored the bactericidal role of the epidermal mucus (EM) of five freshwater Cyprinid fish species namely Ctenopharyngodon idella, Labeo rohita, Catla catla, Hypophthalmichthys molitrix, and Cirrhinus mrigala after treatment with Aeromonas hydrophila. Extracts of EM (crude and acidic) of each species showed bactericidal activity against various Gram −ve (Pseudomonas aeruginosa, Escherichia coli, Aeromonas hydrophila, Edwardsiella tarda, Salmonella enterica, Klebsiella pneumonia, Serratia marcescens, and Enterobacter cloacae) and Gram +ve (Bacillus wiedmannii and Staphylococcus aureus) bacteria compared with standard antibiotics (Fosfomycin). The zone of inhibition (ZOI) was measured in millimetres against antibiotics (Fosfomycin). Variations in bactericidal activity of EM were observed against bacteria from the same and different fish species. The acidic extract was more effective than the crude extract and showed significantly higher ZOI values against various bacteria and Fosfomycin antibiotics. This result shows that fish EM may perform an important role in fish defence against bacteria. Therefore, this study may hint towards the substitution of synthetic antibiotics with fish EM that may be used as a novel ‘bactericidal’ in aquaculture as well as in humans against bacterial infections.

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