Protein-protein binding before and after photo-modification of albumin

Rozinek, Sarah C.; Glickman, Randolph D.; Thomas, Robert J.; Brancaleon, Lorenzo

doi:10.1117/12.2213632

Search citation statements

Order By: Relevance

Paper Sections

Select...

■ Introduction1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2019

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Noncovalent interactions of hydrophilic porphyrins with amino acid residues can lead to coating of the surface of serum proteins such as BSA 96 and HSA. 97 Even highly water-soluble cationic porphyrins can exhibit this behavior. 96 These serum proteins can allow the porphyrin to be chaperoned into the cell by endocytosis.…”

Section: ■ Introductionmentioning

confidence: 99%

Photosensitizer Antibody–Drug Conjugates: Past, Present, and Future

Sandland

Boyle

2019

Bioconjugate Chem.

View full text Add to dashboard Cite

This Review aims to highlight key aspects of tetrapyrrole-based antibody–drug conjugates (ADCs) and significant developments in the field since 2010. Many new conjugation methods have been developed and employed in the past decade, and associated with this, there has been a rising interest in theranostic conjugates. We have investigated the physicochemical properties that tetrapyrroles need to possess in order to be viable photosensitizers for conjugation to antibodies. Differences in conjugation strategies are discussed, and structure–activity relationships of tetrapyrrole–antibody conjugates are reported, where available. As the elegance of bioconjugation techniques has increased, it has paved the way for exceptionally phototoxic, yet highly selective, tetrapyrrole–antibody conjugates, with photocytotoxicities in the nanomolar range, to be synthesized and biologically evaluated.

show abstract

Section: ■ Introductionmentioning

confidence: 99%