Protein quantitation by complexation of fluorescent tetraphenylthiophene cation to anion-terminated poly(N-isopropylacrylamide): Aggregation-enhanced emission and electrostatic interaction

Aggregation and Binding-Directed FRET Modulation of Conjugated Polymer Materials for Selective and Point-of-Care Monitoring of Serum Albumins

“…4,11,22−28 Particularly, the detection of proteins including SAs has been comprehensively achieved 29,30 by employing organic dyes that undergo structural modulation after interactions with surfactant− protein ensembles. However, most of these systems either are less sensitive 4,16 or depend on change in the single emission band, 19,22,23,25,26,29,30 which are usually prone to erratic analyses. Recently, Liu and co-workers 24,31 demonstrated the first point-of-care (PoC) method utilizing small organic probes for competently monitoring albumin in body fluids like serum and urine.…”

“…Several fluorescent probes have been reported − ,− for monitoring SAs via diverse sensing mechanisms. ,,− Particularly, the detection of proteins including SAs has been comprehensively achieved , by employing organic dyes that undergo structural modulation after interactions with surfactant–protein ensembles. However, most of these systems either are less sensitive , or depend on change in the single emission band, ,,,,,, which are usually prone to erratic analyses. Recently, Liu and co-workers , demonstrated the first point-of-care (PoC) method utilizing small organic probes for competently monitoring albumin in body fluids like serum and urine.…”