Protein-Related Dietary Parameters and Frailty Status in Older Community-Dwellers across Different Frailty Instruments

Coelho-Júnior, Hélio José; Calvani, Riccardo; Picca, Anna; Gonçalves, Ivan O; Landi, Francesco; Bernabei, Roberto; Cesari, Matteo; Uchida, Marco Carlos; Marzetti, Emanuele

doi:10.3390/nu12020508

Cited by 32 publications

(28 citation statements)

References 59 publications

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“…A reduced concentration of systemic BCAA is associated with sarcopenia in older adults and patients with LC [ 7 , 27 ]. Furthermore, frail participants showed lower daily consumption of protein and BCAA compared to both pre-frail and robust individuals [ 28 ]. Thus, our results are theoretically reasonable and support the notion that decreased levels of both IGF-1 and BCAA are associated with the development of osteosarcopenia and frailty in patients with CLD.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Osteosarcopenia and Frailty in Patients with Chronic Liver Disease

Saeki

Kanai

Nakano

et al. 2020

JCM

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Osteosarcopenia and frailty have a negative health impact on an aging society. This cross-sectional study aimed to investigate the clinical characteristics and relationship of osteosarcopenia and frailty in 291 patients with chronic liver disease (CLD), who comprised 137 males and 154 females, with a median age of 70.0 years. Sarcopenia was diagnosed according to the Japan Society of Hepatology criteria. Bone mineral density was measured using dual-energy X-ray absorptiometry. Frailty was defined by five parameters (exhaustion, slowness, weakness, low physical activity, and weight loss). Among the 291 patients, 49 (16.8%) and 81 (27.8%) had osteosarcopenia and frailty, respectively. Frailty and vertebral fracture were more frequently noted in patients with osteosarcopenia than in those without osteosarcopenia (79.6% vs. 17.4% and 59.2% vs. 20.2%, respectively; p < 0.001 for both). Meanwhile, osteosarcopenia and vertebral fracture were more frequently observed in patients with frailty than in those without frailty (48.1% vs. 4.8% and 49.4% vs. 18.1%, respectively; p < 0.001 for both). On multivariate analysis, frailty was an independent factor associated with osteosarcopenia (odds ratio (OR), 9.837; p < 0.001), and vice versa (OR, 10.069; p < 0.001). Osteosarcopenia and frailty were prevalent, closely interrelated, and increased the risk of vertebral fracture in patients with CLD.

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Section: Discussionmentioning

confidence: 99%

Relationship between Osteosarcopenia and Frailty in Patients with Chronic Liver Disease

Saeki

Kanai

Nakano

et al. 2020

JCM

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“…The HPD seems to be inversely related to the onset of the fragility state [ 105 ]. Fragility is defined as having at least three of the following five symptoms: weight loss, low physical activity, asthenia, slowing down, and fatigue.…”

Section: Nutritional Therapymentioning

confidence: 99%

Uremic Sarcopenia and Its Possible Nutritional Approach

et al. 2021

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Uremic sarcopenia is a frequent condition present in chronic kidney disease (CKD) patients and is characterized by reduced muscle mass, muscle strength and physical performance. Uremic sarcopenia is related to an increased risk of hospitalization and all-causes mortality. This pathological condition is caused not only by advanced age but also by others factors typical of CKD patients such as metabolic acidosis, hemodialysis therapy, low-grade inflammatory status and inadequate protein-energy intake. Currently, treatments available to ameliorate uremic sarcopenia include nutritional therapy (oral nutritional supplement, inter/intradialytic parenteral nutrition, enteral nutrition, high protein and fiber diet and percutaneous endoscopic gastrectomy) and a personalized program of physical activity. The aim of this review is to analyze the possible benefits induced by nutritional therapy alone or in combination with a personalized program of physical activity, on onset and/or progression of uremic sarcopenia.

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“…This topic deserves attention, given that negative health-related events (e.g., disability and hospitalization) are differentially predicted by various frailty instruments. A recent study by our group [ 122 ] tried to overcome these limitations by investigating the associations between frailty status according to three different frailty assessment tools and (a) daily protein intake, (b) daily BW-adjusted protein intake, (c) BCAA consumption, (d) evenness of protein distribution across main meals, and (e) number of daily meals providing at least 30 g of protein in community-dwelling older adults. The assessment tools used were the Fried’s frailty phenotype, the FRAIL scale, and the Study of Osteoporotic Fracture (SOF) index, which differ in the method used to assess physical function.…”

Section: Future Perspectivesmentioning

confidence: 99%

Protein Intake and Frailty: A Matter of Quantity, Quality, and Timing

et al. 2020

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Frailty is a geriatric syndrome that refers to a state of reduced resiliency to stressful events that occurs in response to physiological and/or psychosocial detriments. Frailty is a predictor of poor prognosis, given that frail older adults are at higher risk of many adverse health-related events. Hence, the identification of potential strategies to prevent the development and progression of frailty is of extreme importance for avoiding its negative outcomes. An adequate protein consumption is advocated as a possible intervention for the management of frailty in older adults due to its effects on muscle mass and physical function. However, empirical evidence is still needed to support this proposition. On the other hand, substantial evidence from observational studies has provided important information on the association between frailty and dietary protein-related parameters. Here, we provide a narrative review of the current literature regarding the association between protein intake (amount (how much?), quality (what type?), and distribution across meals (when?)) and frailty-related parameters. The ultimate aim of this work is to offer practical, evidence-based indications to healthcare professionals responsible for the care of frail older adults.

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Protein-Related Dietary Parameters and Frailty Status in Older Community-Dwellers across Different Frailty Instruments

Cited by 32 publications

References 59 publications

Relationship between Osteosarcopenia and Frailty in Patients with Chronic Liver Disease

Relationship between Osteosarcopenia and Frailty in Patients with Chronic Liver Disease

Uremic Sarcopenia and Its Possible Nutritional Approach

Protein Intake and Frailty: A Matter of Quantity, Quality, and Timing

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