Protein-resistance performance of amphiphilic copolymer brushes consisting of fluorinated polymers and polyacrylamide grafted from silicon surfaces

Wu, Haixia; Tan, Lei; Yang, Meiyan; Liu, Chuan-Jun; Zhuo, Ren‐Xi

doi:10.1039/c4ra16036c

Cited by 20 publications

(17 citation statements)

References 45 publications

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“…To investigate the reason for this, the contact angle of the samples was measured using a contact angle system because the surface wettability can influence the cell adhesion behavior and cell proliferation . From Figure B, it can be seen that the surfaces of Ti and Ti–S–TiO 2– x exhibited hydrophilicity, with contact angles of 69.83° and 35.31°, respectively. , The increased hydrophilicity of Ti–S–TiO 2– x may have resulted from the micro-nanostructure of S-TiO 2– x , which could provide more contact anchors for the filopodia of MC3T3-E1 and then contribute to cell adhesion and proliferation . For observing the cell morphology of the MC3T3-E1 culture on samples, the cytoskeleton and cell nucleus were stained by fluorescein isothiocyanate (FITC) and 4′,6-diamidino-2-phenylindole (DAPI), respectively.…”

Section: Resultsmentioning

confidence: 99%

Rapid Photo-Sonotherapy for Clinical Treatment of Bacterial Infected Bone Implants by Creating Oxygen Deficiency Using Sulfur Doping

et al. 2020

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Periprosthetic infection is considered the main cause of implant failure, which is expected to be solved by fabricating an antibacterial coating on the surface of the implant. Nevertheless, systemic antibiotic treatment still represents the mainstream method for preventing infection, and few antibacterial coatings are applied clinically. This is because the externally introduced traditional antibacterial coatings suffer from the risk of invalidation and tissue toxicity induced by the consumption of antibacterial agents, degradation, and shedding. In this work, we proposed a rapid photo-sonotherapy by creating an oxygen deficiency on a titanium (Ti) implant through sulfur (S)-doping (Ti–S–TiO2–x ), which endowed the implants with great sonodynamic and photothermal ability. Without introducing an external antibacterial coating, it reached a high antibacterial efficiency of 99.995% against Staphylococcus aureus under 15 min near-infrared light and ultrasound treatments. Furthermore, bone infection was successfully treated after combination treatments, and improved osseointegration was observed. Importantly, the S-doped Ti implant immersed in water for 6 months showed an unchanged structure and properties, suggesting that the Ti implant with intrinsic modification showed stable antibacterial performance under exogenous stimuli with a high antibacterial performance in vivo. This photo-sonotherapy based on sulfur doping is also promising for cancer therapy with biosafety.

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Section: Resultsmentioning

confidence: 99%

Rapid Photo-Sonotherapy for Clinical Treatment of Bacterial Infected Bone Implants by Creating Oxygen Deficiency Using Sulfur Doping

et al. 2020

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“…There are two signals of C1s and O1s core levels observed on the surface of neat PLA film, while for those of both grafted PLA films, an additional signal of N1s is detected, which is assigned to the N constituent from PAm-grafted chains. 44,45 The scaleexpanded spectra in core level regions, i.e., C1s, N1s, and O1s, of all samples are compared in Fig. 3x-z 46 The corresponding spectra of grafted films show 47,48 It is assumed that the g-PLA(RF) film surface has a higher degree of chain scissions, compared to the g-PLA(CQ) counterpart, as reflected from its lower intensities.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Quantitative Analysis of Polyacrylamide Grafted on Polylactide Film Surfaces Employing Spectroscopic Techniques

Rahman

Opaprakasit

2017

Appl Spectrosc

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Standard techniques for quantitative measurement of polyacrylamide (PAm) contents grafted on polylactide (PLA) film substrates, P(LA- g-Am- co-MBAm), which are commonly used as cell culture substrates or scaffolds, and pH-sensitive absorbents have been developed with X-ray photoelectron (XPS), proton-nuclear magnetic resonance (H-NMR), and Fourier transform infrared (FT-IR) spectroscopy. The techniques are then applied to examine P(LA- g-Am- co-MBAm) samples prepared from two separate photo-initiator/co-initiator systems. Efficiency and accuracy of the techniques are compared. The results from all techniques are in good agreement, indicating high analysis precisions, although FT-IR technique provides additional advantages, in terms of short analysis time, ease of sample preparation, and accessibility of a machine. The results indicate that the riboflavin (RF) initiator system has higher grafting efficiency than its camphorquinone (CQ) counterpart. These standard techniques can be applied in the analysis of these materials and further modified for quantitative analysis of other grafting systems.

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“…Figures 5(a) and 5(b) show 2 strong signals of C1s and O1s for the surfaces of both samples, while a distinct N1s signal of PAm is only observed in the grafted sample [31,32]. The presence of this signal ultimately indicates the success of the photografting reaction.…”

Section: Xps Analysismentioning

confidence: 90%

Development and Characterization of Photoinduced Acrylamide-Grafted Polylactide Films for Biomedical Applications

Rahman

Sreearunothai

Opaprakasit

2017

International Journal of Polymer Science

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Surface grafting of biodegradable/biocompatible polylactide (PLA) films by a UV-assisted reaction has been developed by employing a hydrophilic acrylamide (Am) monomer, an N,N -methylenebisacrylamide (MBAm) cross-linker, and a camphorquinone (CQ)/N,N -dimethylaminoethylmethacrylate (DMAEMA) photoinitiator/coinitiator system. The accomplishment of the process is confirmed by FTIR and XPS analyses. Physicochemical changes of the grafted PLA films are evaluated in terms of chemical structures, radiation-induced degradation followed by crystallization, morphology, thermal properties, and mechanical behavior. The results reveal that a low degree of PLA degradation through chain scission is observed in both blank and grafted PLA films. This generates more polar chain ends that can further induce crystallization. Results from contact angle measurements indicate that the grafted films have higher hydrophilicity and pH-responsive behavior. The incorporation of PAm on the film's surface and the induced crystallization lead to improvements in certain aspects of mechanical properties of the films. The materials have high potential for use in biomedical and environmental applications, such as cell culture substrates or scaffolds or pH-sensitive absorbents.

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Protein-resistance performance of amphiphilic copolymer brushes consisting of fluorinated polymers and polyacrylamide grafted from silicon surfaces

Abstract: A series of random copolymer brushes of acrylamide (AM) and 2-(perfluorinated hexyl)ethyl methacrylate (FMA) were grafted from initiator-functionalized silicon wafers by surface-initiated atom transfer radical polymerization.

Cited by 20 publications

References 45 publications

Rapid Photo-Sonotherapy for Clinical Treatment of Bacterial Infected Bone Implants by Creating Oxygen Deficiency Using Sulfur Doping

Rapid Photo-Sonotherapy for Clinical Treatment of Bacterial Infected Bone Implants by Creating Oxygen Deficiency Using Sulfur Doping

Quantitative Analysis of Polyacrylamide Grafted on Polylactide Film Surfaces Employing Spectroscopic Techniques

Development and Characterization of Photoinduced Acrylamide-Grafted Polylactide Films for Biomedical Applications

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