Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny

Furuse, Tamio; Miyake, Kunio; Kohda, Takashi; Kaneda, Hideki; Hirasawa, Takae; Yamada, Ikuko; Kushida, Tomoko; Kashimura, Masami; Kobayashi, Kimio; Ishino, Fumitoshi; Kubota, Takeo; Wakana, Shigeharu

doi:10.1186/s12263-016-0550-2

Cited by 28 publications

(19 citation statements)

References 42 publications

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“…This means that our brain circuitry is still programmed to eat more in times of food abundance preparing for periods of starvation ( 31 ). Recent genetic studies have focused on gene polymorphisms related to specific nutrients and obesity ( 34 – 37 ). This area of investigation has been called nutrigenetics and suggests that epigenetic factors influence the expression of predisposing genes in certain populations.…”

Section: Evolutionary and Genetic Aspects Of Feedingmentioning

confidence: 99%

Sugar Addiction: From Evolution to Revolution

2018

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The obesity epidemic has been widely publicized in the media worldwide. Investigators at all levels have been looking for factors that have contributed to the development of this epidemic. Two major theories have been proposed: (1) sedentary lifestyle and (2) variety and ease of inexpensive palatable foods. In the present review, we analyze how nutrients like sugar that are often used to make foods more appealing could also lead to habituation and even in some cases addiction thereby uniquely contributing to the obesity epidemic. We review the evolutionary aspects of feeding and how they have shaped the human brain to function in “survival mode” signaling to “eat as much as you can while you can.” This leads to our present understanding of how the dopaminergic system is involved in reward and its functions in hedonistic rewards, like eating of highly palatable foods, and drug addiction. We also review how other neurotransmitters, like acetylcholine, interact in the satiation processes to counteract the dopamine system. Lastly, we analyze the important question of whether there is sufficient empirical evidence of sugar addiction, discussed within the broader context of food addiction.

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Section: Evolutionary and Genetic Aspects Of Feedingmentioning

confidence: 99%

Sugar Addiction: From Evolution to Revolution

2018

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“…This finding is not particularly surprising given that the effects of exposure to PD on anxiety-like behavior have been equivocal across published studies. 30,33,75–78 We did observe a significant diet-by-RIX effect on all 3 measures of anxiety-like behavior and stress response (Table 1). These data in combination with conflicting results in the literature support a hypothesis that the effects of exposure to PD on anxiety and stress response are dependent on genetic background.…”

Section: Discussionmentioning

confidence: 76%

Perinatal nutrition interacts with genetic background to alter behavior in a parent‐of‐origin‐dependent manner in adult Collaborative Cross mice

Schoenrock

Oreper

Farrington

et al. 2017

Genes Brain and Behavior

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Previous studies in animal models and humans have shown that exposure to nutritional deficiencies in the perinatal period increases the risk of psychiatric disease. Less well understood is how such effects are modulated by the combination of genetic background and parent-of-origin (PO). To explore this, we exposed female mice from 20 Collaborative Cross (CC) strains to protein deficient, vitamin D deficient, methyl donor enriched or standard diet during the perinatal period. These CC females were then crossed to a male from a different CC strain to produce reciprocal F1 hybrid females comprising 10 distinct genetic backgrounds. The adult F1 females were then tested in the open field, light/dark, stress-induced hyperthermia, forced swim and restraint stress assays. Our experimental design allowed us to estimate effects of genetic background, perinatal diet, PO and their interactions on behavior. Genetic background significantly affected all assessed phenotypes. Perinatal diet exposure interacted with genetic background to affect body weight, basal body temperature, anxiety-like behavior and stress response. In 8 of 9 genetic backgrounds, PO effects were observed on multiple phenotypes. Additionally, we identified a small number of diet-by-PO effects on body weight, stress response, anxiety- and depressive-like behavior. Our data show that rodent behaviors that model psychiatric disorders are affected by genetic background, PO and perinatal diet, as well as interactions among these factors.

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“…Units used for calculations of the indices were in mg/dL for glucose and U/L for insulin. Using the data of DiOGenes [ 22 ], CORDIOPREV [ 23 ], and PhenFlex [ 24 , 25 ] studies, cut-off values for MISI were determined. These values were calculated and validated by using data of more than 1000 subjects with different health status: healthy subjects, subjects with prediabetes, and patients with undiagnosed and clinically diagnosed type 2 diabetes.…”

Section: Methodsmentioning

confidence: 99%

Obese Older Type 2 Diabetes Mellitus Patients with Muscle Insulin Resistance Benefit from an Enriched Protein Drink during Combined Lifestyle Intervention: The PROBE Study

et al. 2020

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(1) Background: Recent research showed that subtypes of patients with type 2 diabetes may differ in response to lifestyle interventions based on their organ-specific insulin resistance (IR). (2) Methods: 123 Subjects with type 2 diabetes were randomized into 13-week lifestyle intervention, receiving either an enriched protein drink (protein+) or an isocaloric control drink (control). Before and after the intervention, anthropometrical and physiological data was collected. An oral glucose tolerance test was used to calculate indices representing organ insulin resistance (muscle, liver, and adipose tissue) and β-cell functioning. In 82 study-compliant subjects (per-protocol), we retrospectively examined the intervention effect in patients with muscle IR (MIR, n = 42) and without MIR (no-MIR, n = 40). (3) Results: Only in patients from the MIR subgroup that received protein+ drink, fasting plasma glucose and insulin, whole body, liver and adipose IR, and appendicular skeletal muscle mass improved versus control. Lifestyle intervention improved body weight and fat mass in both subgroups. Furthermore, for the MIR subgroup decreased systolic blood pressure and increased VO2peak and for the no-MIR subgroup, a decreased 2-h glucose concentration was found. (4) Conclusions: Enriched protein drink during combined lifestyle intervention seems to be especially effective on increasing muscle mass and improving insulin resistance in obese older, type 2 diabetes patients with muscle IR.

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Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny

Cited by 28 publications

References 42 publications

Sugar Addiction: From Evolution to Revolution

Sugar Addiction: From Evolution to Revolution

Perinatal nutrition interacts with genetic background to alter behavior in a parent‐of‐origin‐dependent manner in adult Collaborative Cross mice

Obese Older Type 2 Diabetes Mellitus Patients with Muscle Insulin Resistance Benefit from an Enriched Protein Drink during Combined Lifestyle Intervention: The PROBE Study

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