Protein restriction for children with chronic kidney disease

Chaturvedi, Swasti; Jones, Colin L.

doi:10.1002/14651858.cd006863

Cited by 36 publications

(19 citation statements)

References 42 publications

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“…Although the effects of a lowprotein diet on the progression of CKD has been the subject of controversy, a protein restriction of 0.6-0.8 g/kg/day is recommended in adult patients with end-stage CKD (Fouque and Aparicio 2007). In contrast, a protein-restricted diet seems to have no significant impact on the progression of CKD in children (Wingen et al 1997;Chaturvedi and Jones 2007). Thus, at the current state of knowledge, recommendations for protein intake in PKU patients with CKD are difficult to establish.…”

Section: Discussionmentioning

confidence: 99%

Chronic kidney disease in adolescent and adult patients with phenylketonuria

Hennermann

Roloff

Gellermann

et al. 2012

J of Inher Metab Disea

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Section: Discussionmentioning

confidence: 99%

Chronic kidney disease in adolescent and adult patients with phenylketonuria

Hennermann

Roloff

Gellermann

et al. 2012

J of Inher Metab Disea

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“…Although dietary protein restriction in an animal model of ADPKD was associated with decreased kidney cyst volume and improved renal function [64], similar effects were not observed in ADPKD adult humans, albeit in the setting of advanced structural and functional disease [65]. Regardless, dietary protein restriction is not advocated in growing children including those with chronic kidney disease [66]; however, excessive protein intake should be avoided with underlying renal disease. To date, no specific diet has been studied in or advocated for children with ADPKD.…”

Section: Supportive Treatmentmentioning

confidence: 99%

Autosomal dominant polycystic kidney disease in children

Cadnapaphornchai

2015

Current Opinion in Pediatrics

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Purpose of review Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disease, affecting one in 500 individuals. The cardinal manifestation of ADPKD is progressive cystic dilatation of renal tubules with kidney enlargement and progression to end-stage renal disease in approximately half of cases by 60 years of age. Although previously considered a condition of adults, it is clear that children and young adults are subject to the complications of ADPKD. Recent findings It has been increasingly recognized that interventions early in life are necessary in order to confer the best long-term outcome in this common condition. Therefore, it is imperative for pediatricians to recognize the manifestations and complications of this disease. Until recently ADPKD management focused on general principles of chronic kidney disease. However, several recent clinical trials in children and adults with ADPKD have focused on disease-specific therapies. Summary This review will highlight the clinical manifestations, diagnosis, and appropriate management of ADPKD in childhood and will review recent relevant clinical trials in children and adults with this condition.

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“…After 2 years of follow-up, neither the primary endpoint (change in creatinine clearance) nor growth was different between the two groups (53). A Cochrane meta-analysis in 2007 concluded that there was uncertainty over the possibility of harm associated with the provision of strict low protein diets on growth in young infants (54).…”

Section: Evidence and Rationalementioning

confidence: 99%

Energy and protein requirements for children with CKD stages 2-5 and on dialysis–clinical practice recommendations from the Pediatric Renal Nutrition Taskforce

et al. 2019

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Dietary management in pediatric chronic kidney disease (CKD) is an area fraught with uncertainties and wide variations in practice. Even in tertiary pediatric nephrology centers, expert dietetic input is often lacking. The Pediatric Renal Nutrition Taskforce (PRNT), an international team of pediatric renal dietitians and pediatric nephrologists, was established to develop clinical practice recommendations (CPRs) to address these challenges and to serve as a resource for nutritional care. We present CPRs for energy and protein requirements for children with CKD stages 2-5 and those on dialysis (CKD2-5D). We address energy requirements in the context of poor growth, obesity, and different levels of physical activity, together with the additional protein needs to compensate for dialysate losses. We describe how to achieve the dietary prescription for energy and protein using breastmilk, formulas, food, and dietary supplements, which can be incorporated into everyday practice. Statements with a low grade of evidence, or based on opinion, must be considered and adapted for the individual patient by the treating physician and dietitian according to their clinical judgment. Research recommendations have been suggested. The CPRs will be regularly audited and updated by the PRNT.

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Protein restriction for children with chronic kidney disease

Abstract: Reducing protein intake does not appear to have significant impact in delaying the progression to ESKD in children.

Cited by 36 publications

References 42 publications

Chronic kidney disease in adolescent and adult patients with phenylketonuria

Chronic kidney disease in adolescent and adult patients with phenylketonuria

Autosomal dominant polycystic kidney disease in children

Energy and protein requirements for children with CKD stages 2-5 and on dialysis–clinical practice recommendations from the Pediatric Renal Nutrition Taskforce

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