Protein secondary structure prediction based on Wasserstein generative adversarial networks and temporal convolutional networks with convolutional block attention modules

Abstract

<abstract> <p>As an important task in bioinformatics, protein secondary structure prediction (PSSP) is not only beneficial to protein function research and tertiary structure prediction, but also to promote the design and development of new drugs. However, current PSSP methods cannot sufficiently extract effective features. In this study, we propose a novel deep learning model WGACSTCN, which combines Wasserstein generative adversarial network with gradient penalty (WGAN-GP), convolutional block attention module (CBAM) and temporal convolutional network (TCN) for 3-state and 8-state PSSP. In the proposed model, the mutual game of generator and discriminator in WGAN-GP module can effectively extract protein features, and our CBAM-TCN local extraction module can capture key deep local interactions in protein sequences segmented by sliding window technique, and the CBAM-TCN long-range extraction module can further capture the key deep long-range interactions in sequences. We evaluate the performance of the proposed model on seven benchmark datasets. Experimental results show that our model exhibits better prediction performance compared to the four state-of-the-art models. The proposed model has strong feature extraction ability, which can extract important information more comprehensively.</p> </abstract>

SERT-StructNet: Protein secondary structure prediction method based on multi-factor hybrid deep model

“…To evaluate the performance of the proposed SERT-StructNet, we compared and assessed six existing protein secondary structure prediction methods on the same test dataset: DeepCNF [12] , RaptorX-SS [13] , JPRED [14] , Porter 5 [15] , Protein Encoder [19] and WGACSTCN [32] . In Table 2 , we present the accuracy and Sov of the SERT-StructNet method and other prediction methods on the same test set to obtain a more comprehensive understanding of the advantages or disadvantages of the performance of the SERT-StructNet method with respect to the other methods.…”