2014
DOI: 10.1021/la5033465
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Protein–Silver Nanoparticle Interactions to Colloidal Stability in Acidic Environments

Abstract: We report a kinetic study of Ag nanoparticles (AgNPs) under acidic environments (i.e., pH 2.3 to pH ≈7) and systematically investigate the impact of protein interactions [i.e., bovine serum albumin (BSA) as representative] to the colloidal stability of AgNPs. Electrospray-differential mobility analysis (ES-DMA) was used to characterize the particle size distributions and the number concentrations of AgNPs. Transmission electron microscopy was employed orthogonally to provide visualization of AgNPs. For unconju… Show more

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Cited by 63 publications
(84 citation statements)
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“…29 Cl − has been suggested to play a role in particle aggregation by aiding in the formation of interparticle AgCl bridges. 31 What makes the interpretation of the previous data particularly challenging is that many have used an initial time point of examination greater than 10 min, 26,27 meaning that there is a dearth of data within a key time window during which particles are undergoing their most rapid modification. Additionally, previous work has focused on highly acidic conditions of pH 2 or less, 29,30 which represent only fasted, not fed, stomach conditions.…”
Section: Introductionmentioning
confidence: 99%
“…29 Cl − has been suggested to play a role in particle aggregation by aiding in the formation of interparticle AgCl bridges. 31 What makes the interpretation of the previous data particularly challenging is that many have used an initial time point of examination greater than 10 min, 26,27 meaning that there is a dearth of data within a key time window during which particles are undergoing their most rapid modification. Additionally, previous work has focused on highly acidic conditions of pH 2 or less, 29,30 which represent only fasted, not fed, stomach conditions.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, recent investigations conferred that the use of ES-DMA benefits from advantages such as discernment of particle aggregation from the dissolution process and high-resolution particle size measurements [66,67]. Moreover, ES-DMA allows for accurate quantification of ligands bound to AgNPs [61].…”
Section: Agglomeration and Stabilization Of Agnpsmentioning
confidence: 99%
“…To investigate the primary size and the morphology of individual nanoparticles, positively-charged aerosolized particles were delivered to a home-made electrostatic precipitator and deposited onto a copper grid with carbon film operated at a sample flow rate of %1.5 L/min and À(2-5) kV/cm electric field. Due to the electrostatic repulsion, the deposition-induced aggregation was negligible during sample collection [27,28,33,34]. The drop-cast method was also employed to prepare samples used for the study of surface dissolution of nanoparticles.…”
Section: Transmission Electron Microscopy (Tem)mentioning
confidence: 99%
“…Folded capillary disposal cells were used under an ionic strength of %2 mmol/L NaCl aqueous solution. Results were converted from the measured electrophoretic mobility to zeta potential using the Smoluchowski approximation [33,36].…”
Section: Zeta Potential Analysismentioning
confidence: 99%
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