Protein Supplementation for the Prevention and Management of Sarcopenia in the Elderly

Li, Na; Wang, Jia Jia; Lu, Zong Liang; Zhu, Meiling; Xu, Hong; Liu, Jie

doi:10.34175/jno201902004

Cited by 1 publication

(18 citation statements)

References 64 publications

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“…p70S6K is a positive regulator of mTORC1/protein synthesis, which phosphorylates ribosomal protein S6, thereby selectively translating 5′-terminal polypyrimidine mRNA encoding ribosomal protein and translation factor . Then, it stimulates protein translation by promoting the formation of translation complexes, thus regulating the synthesis rate of muscle protein . 4E-BP1 is a negative regulator of mTORC1/protein synthesis .…”

Section: Mechanism Of Antisarcopenic Peptides In Alleviating Sarcopeniamentioning

confidence: 99%

“…For example, the effect of phosphorylation of 4E-BP1 on MPS remains controversial. Some researchers reported that this process promoted MPS, while some found its inhibitory effect on MPS . In addition, the action modes of antisarcopenic peptides on muscle synthesis as well as the exact mechanism or pathway need to be further clarified …”

Section: Mechanism Of Antisarcopenic Peptides In Alleviating Sarcopeniamentioning

confidence: 99%

“…Therefore, supplementation of amino acids, proteins, and protein synthesis promoters is an important way to overcome the reduction in food intake, digestion, and absorption in the elderly and prevent sarcopenia. 49 Essential amino acids (EAA) are the main factors that stimulate MPS. Among them, branched-chain amino acids (BCAA), including Leu, Ile, and Val, play an important role in the prevention and treatment of sarcopenia.…”

Section: Diagnosis and Mitigation Of Sarcopeniamentioning

confidence: 99%

“…Among them, branched-chain amino acids (BCAA), including Leu, Ile, and Val, play an important role in the prevention and treatment of sarcopenia. 49 Among BCAA, Leu has received more attention. It is reported that Leu has a positive effect on protein turnover in the regulation of skeletal muscle anabolism, protein synthesis, and autophagy.…”

Section: Diagnosis and Mitigation Of Sarcopeniamentioning

confidence: 99%

“…51 Moreover, adequate energy and protein intake are the main approaches to stimulating MPS. 49 Whey protein supplementation was reported to augment the synthesis of leg lean mass and muscle protein. 52 Therefore, protein supplementation may slow down muscle atrophy, especially in the elderly with habitual low protein intake.…”

Section: Diagnosis and Mitigation Of Sarcopeniamentioning

confidence: 99%

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Potential of Food Protein-Derived Bioactive Peptides against Sarcopenia: A Comprehensive Review

Zhu

Wang

et al. 2023

J. Agric. Food Chem.

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Sarcopenia is an age-related progressive muscle disorder characterized by accelerated loss of muscle mass, strength, and function, which are important causes of physiological dysfunctions in the elderly. At present, the main alleviating method includes protein supplements to stimulate synthesis of muscle proteins. Food protein-derived peptides containing abundant branched-chain amino acids have a remarkable effect on the improvement of sarcopenia. Understanding the underlying molecular mechanism and clarifying the structure–activity relationship is essential for the mitigation of sarcopenia. This present review recaps the epidemiology, pathogenesis, diagnosis, and treatment of sarcopenia, which facilitates a comprehensive understanding of sarcopenia. Moreover, the latest research progress on food-derived antisarcopenic peptides is reviewed, including their antisarcopenic activity, molecular mechanism as well as structural characteristics. Food-derived bioactive peptides can indeed alleviate/mitigate sarcopenia. These antisarcopenic peptides play a pivotal role mainly by activating the PI3K/Akt/mTOR and MAPK pathways and inhibiting the ubiquitin-proteasome system and AMPK pathway, thus promoting the synthesis of muscle proteins and inhibiting their degradation. Antisarcopenic peptides alleviate sarcopenia via specific peptides, which may be absorbed into the circulation and exhibit their bioactivity in intact forms. The present review provides a theoretical reference for mitigation and prevention of sarcopenia by food protein-derived bioactive peptides.

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Section: Mechanism Of Antisarcopenic Peptides In Alleviating Sarcopeniamentioning

confidence: 99%

Section: Mechanism Of Antisarcopenic Peptides In Alleviating Sarcopeniamentioning

confidence: 99%

Section: Diagnosis and Mitigation Of Sarcopeniamentioning

confidence: 99%

Section: Diagnosis and Mitigation Of Sarcopeniamentioning

confidence: 99%

Section: Diagnosis and Mitigation Of Sarcopeniamentioning

confidence: 99%

See 3 more Smart Citations

Potential of Food Protein-Derived Bioactive Peptides against Sarcopenia: A Comprehensive Review

Zhu

Wang

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

Protein Supplementation for the Prevention and Management of Sarcopenia in the Elderly

Cited by 1 publication

References 64 publications

Potential of Food Protein-Derived Bioactive Peptides against Sarcopenia: A Comprehensive Review

Potential of Food Protein-Derived Bioactive Peptides against Sarcopenia: A Comprehensive Review

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