Protein supplementation improves the performance of parasitised sheep fed a straw-based diet

Datta, Frans Umbu; Nolan, JV; Rowe, Jeffrey E.; Gray, G. D.

doi:10.1016/s0020-7519(98)00104-0

Cited by 64 publications

(37 citation statements)

References 12 publications

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“…One reason for this might be that eosinophilia should have been measured locally rather than in peripheral blood. Nonetheless, it has been shown that in parasitized sheep a high protein diet could increase eosinophils counts and attenuate physiopathological effects of haemonchosis (Datta et al, 1998). The subclinical haemonchosis observed in our experiment where resistant and susceptible animals showed no differences in eosinophilia, is in keeping with this previous study, but this hypothesis needs further experiments to be validated.…”

Section: Discussionsupporting

confidence: 91%

Serum antibody responses in Creole kids experimentally infected with Haemonchus contortus

Bambou¹,

Chevrotière²,

Varo³

et al. 2008

Veterinary Parasitology

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The objective of this study was to evaluate the relationship of parasite-specific serum antibodies with the resistance status of Creole kids. The average breeding values on egg output predicted in a context of natural infection at 11 months of age were distant of 1.07 genetic standard deviation between resistant and susceptible animals. After drenching the animals were maintained worm-free during 1 month until experimental infection with 10,000 Haemonchus contortus infective larvae (L3). Enzyme-linked immunosorbent assay was carried out in serum samples to determine the level of IgG, IgA and IgE anti-H. contortus L3 crude extracts and adult excretion/secretion products (ESP). Parasitological and blood immunological parameters were measured on the 2 extreme groups. Despite the absence of any typical signs of haemonchosis, susceptible kids had more than 11 times higher faecal egg counts (FEC) at 35 days post-infection (d.p.i.) than resistant kids had. Levels of immunoglobulin against H. contortus L3 and ESP increased significantly after infection in both groups. However, no difference in the host immune response mediated by immunoglobulin against H. contortus was evidenced between groups. This finding suggests that, in goats previously infected by H. contortus, a degree of protection occurred and the phenotypic and genetic segregation in resistant and susceptible animals were not related to the humoral immune response. The correlation coefficients between FEC and IgE anti-ESP (r = 0.593; P < 0.05 was significant in both resistant and susceptible animals. Such correlation suggesting a hypersensitivity reaction dependent on worm prolificacy has never been described. This result needs further studies to understand the mechanisms underlying this observation. #

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Section: Discussionsupporting

confidence: 91%

Serum antibody responses in Creole kids experimentally infected with Haemonchus contortus

Bambou¹,

Chevrotière²,

Varo³

et al. 2008

Veterinary Parasitology

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“…The mean reduction in VFI during days 21-63 tended to be greater in L-IF than in H-IF animals (0.25 and 0.15, respectively), a finding consistent with that of Kyriazakis et al (1996) who observed 0.18 and 0.11 reductions in VFI in sheep offered diets containing 86 and 206 g CP/kg DM, respectively, when infected with the same nematode species as the present sheep. Similar findings have been observed in infections with Haemonchus contortus (Abbott et al, 1988;Datta et al, 1998) and with urea supplementation during mixed infections with H. contortus and T. colubriformis (Knox and Steel, 1999). While there are examples in the literature during monospecific infections with T. colubriformis where increasing urea (Knox and Steel, 1999) or increasing dietary protein intake (Kahn et al, 2000) has not resulted in amelioration of the reduction in intake, the results from a majority of the studies appear to be consistent with the notion that diets with greater dietary protein concentrations may enable a more rapid transition to an acquired immune response and, consequently, a less-prolonged and severe period of pathophysiology with its associated reduction in appetite.…”

Section: Discussionsupporting

confidence: 88%

Protein supply influences the nutritional penalty associated with the development of immunity in lambs infected with Trichostrongylus colubriformis

Greer

Sedcole

Jay

et al. 2009

Animal

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The influence of dietary protein supply on the nutritional penalty associated with the acquisition phase of the immune response to gastrointestinal nematodes in lambs was investigated. Groups of lambs were offered either a low-protein diet (L; 62 g metabolizable protein (MP)/kg dry matter (DM)) or high-protein diet (H; 95 g MP/kg DM) while being either infected with the equivalent of 2.000 L3 Trichostrongylus colubriformis/day (IF), similarly infected and concurrently immuno-suppressed with methylprednisolone acetate (ISIF), immuno-suppressed only (IS) or kept as uninfected controls (C). Body composition of all animals was measured on days 28 and 76 of infection using X-ray computed tomography. Temporal changes in serum phosphate and serum albumin concentrations, which provided an indicator of pathological damage, in addition to patterns of total daily nematode egg excretion and comparative worm burdens at slaughter indicated that a protective immune response was developed in H-IF, but not L-IF, H-ISIF or L-ISIF groups. Compared to their respective non-infected controls, the gross efficiency of use of metabolizable energy (ME) for net energy (NE) deposition in the carcass was reduced by 0.23 in H-IF (P , 0.05), 0.13 in H-ISIF (P . 0.05), 0.49 in L-IF (P , 0.01) and 0.23 in L-ISIF (P . 0.05). It is concluded that the reduction in ME utilization and reduced performance, which can be attributed to the immunological response, are lessened in animals offered a high-protein diet. Furthermore, evidence is presented to indicate a possible association between T. colubriformis L3 IgA antibody production and loss of performance in lambs infected with this nematode.

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“…Such results have been recorded in lambs infected with the main species of the trichostrongyle nematode: Teladorsagia circumcincta [10]; T. colubriformis [24] or H. contortus [1,11]. In contrast, there are few studies on goats and they provide equivocal results.…”

Section: Discussionmentioning

confidence: 98%

The effect of two levels of dietary protein on resistance and resilience of dairy goats experimentally infected with Trichostrongylus colubriformis: comparison between high and low producers

et al. 2000

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-Numerous studies have examined the interactions between protein nutrition and the response to nematode parasitism in sheep, but very few in goats. Compared with other ruminants, goats are less resistant to nematode infection. In addition, in dairy goats, high producing animals have been shown to be less resistant and less resilient to infection compared to low producing ones. The objective of the present study was to examine the consequences of protein supplementation on both resistance and resilience of dairy goats to nematode trickle infection, taking into account the initial level of milk production of the animals. During a 14-week period, 40 milking goats received a high protein (HP) diet supplying 130% of the protein requirements, and 38 goats were fed a intermediate protein (IP) diet (120% of the protein requirements). In addition, half of each group was given a weekly trickle infection with Trichostrongylus colubriformis larvae, the other part of the flock remained non-infected. Faecal egg counts (FEC), eosinophil counts and pathophysiological data (urea, albumin and inorganic phosphate concentrations in the serum) were measured twice a month. Milk production data (milk yield, protein and fat contents) were also recorded every 15 days. The results showed that FECs were lower (p < 0.05) and eosinophil counts higher (p < 0.05) in the animals receiving the HP diet suggesting that resistance was enhanced by protein supplementation. Meanwhile, milk parameters (related to resilience) were not affected by the level of protein in the diet when considering the whole groups. In contrast, in the high producing goats, the milk production and milk composition parameters were improved with the HP diet. To conclude, we have seen that the expression Vet. Res. 31 (2000) 247-258 247

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Protein supplementation improves the performance of parasitised sheep fed a straw-based diet

Cited by 64 publications

References 12 publications

Serum antibody responses in Creole kids experimentally infected with Haemonchus contortus

Serum antibody responses in Creole kids experimentally infected with Haemonchus contortus

Protein supply influences the nutritional penalty associated with the development of immunity in lambs infected with Trichostrongylus colubriformis

The effect of two levels of dietary protein on resistance and resilience of dairy goats experimentally infected with Trichostrongylus colubriformis: comparison between high and low producers

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