Protein Synthesis and Memory

Chapouthier, Georges

doi:10.1016/b978-0-12-213460-9.50007-1

Cited by 3 publications

(1 citation statement)

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“…Arginine vasopressin (AVP) influences diuresis and vascular resistance. The pegtide has also been reported to affect higher integrative functions of the brain, including memory, attention, and avoidance behavior (DeWied, 1971;Koob and Floyd, 1982;Chapouthier, 1983).…”

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confidence: 99%

Saturable Retention of Vasopressin by Hippocampus Vessels In Vivo, Associated with Inhibition of Blood‐Brain Transfer of Large Neutral Amino Acids

Reith¹,

Ermisch

Diemer

et al. 1987

Journal of Neurochemistry

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Vasopressin receptors have been reported in the endothelium of brain capillaries. The function of these receptors is not known. To test the prediction that vasopressin receptors in brain capillary endothelium affect amino acid transport across the blood-brain barrier and to assess the role of vasopressin transport across the cerebral vascular endothelium, we measured (a) the endothelial permeability to the large neutral amino acid leucine in the absence and presence of arginine vasopressin (AVP) and (b) the permeability of the blood-brain barrier to AVP relative to manitol. In brain regions protected by the blood-brain barrier, after circulation for 20 s, coinjection of leucine and AVP intravenously led to a decrease of leucine transport unrelated to changes of blood flow. The decrease was most pronounced in hippocampus (42%) and least pronounced in olfactory bulb and colliculi (17 and 19%, respectively). In the latter regions, the endothelial permeability to AVP did not significantly exceed that of mannitol. In hippocampus and in regions with no blood-brain barrier (pituitary and pineal glands), AVP retention in excess of mannitol retention was blocked by unlabeled AVP. The findings do not contradict the hypothesis of a role for AVP in the regulation of large neutral amino acid transfer into brain tissue.

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confidence: 99%

Saturable Retention of Vasopressin by Hippocampus Vessels In Vivo, Associated with Inhibition of Blood‐Brain Transfer of Large Neutral Amino Acids

Reith¹,

Ermisch

Diemer

et al. 1987

Journal of Neurochemistry

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Learning and Memory

Donovan

1988

Humors, Hormones and the Mind

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Traditional Chinese Herbs Against Hypertension Enhance the Effect of Memory Acquisition

Lai

et al. 2005

Am. J. Chin. Med.

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Recent findings of a link between high blood pressure (BP) and dementia have given new prospects. The aim of this study is to analyze a mixture of Chinese herbs, Tianma Gouteng Decoction (TGD), which was traditionally used to treat hypertension, and investigate its relation to ameliorating cognitive impairment. We discovered that TGD also had properties involving enhancement of memory acquisition (learning) skills in mice, but not memory consolidation. It was observed that TGD could prolong the step-through latency at doses of 1.0 and 2.5 g/kg on passive avoidance task in mice. TGD could be developed further to treat mice with amnesia, which was induced by scopolamine at the same dose under long-term (8 days) administration.

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Protein Synthesis and Memory

Cited by 3 publications

References 225 publications

Saturable Retention of Vasopressin by Hippocampus Vessels In Vivo, Associated with Inhibition of Blood‐Brain Transfer of Large Neutral Amino Acids

Saturable Retention of Vasopressin by Hippocampus Vessels In Vivo, Associated with Inhibition of Blood‐Brain Transfer of Large Neutral Amino Acids

Learning and Memory

Traditional Chinese Herbs Against Hypertension Enhance the Effect of Memory Acquisition

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