Proteína C reativa: aplicações clínicas e propostas para utilização racional

Abstract

C-reactive protein (CRP) is an acute-phase protein whose requests have been growing exponentially in several countries, including Brazil. In this study, the use of CRP in several clinical situations was reviewed by a group of physicians comprised by specialists in internal medicine, medical emergencies, intensive care, screening, and laboratory medicine, aiming to analyze the applicable literature and to propose guidelines for a more rational use of this laboratory test. The result was the creation of flowcharts guiding CRP request, adjusted to four different healthcare environments, namely, intensive care units, emergency room, wards, and outpatient clinics. These flowcharts, as well as a more detailed discussion on several clinical recommendations for the test, are presented in this study.

Early second-trimester plasma protein profiling using multiplexed isobaric tandem mass tag (TMT) labeling predicts gestational diabetes mellitus

“…b The intensity of each band was measured using imaging analysis. c Proteome profiles of the four proteins in total protein extracts with LC-MS/MS analyses [30]. Plasma CRP concentration is usually low in normal individuals but can be up-regulated rapidly in response to injury, infection and other inflammatory stimuli [31,32].…”

Avaliação da resposta inflamatória sistêmica induzida por carcinoma ductal in situ em cadelas

“…A PCR geralmente se eleva em processos inflamatórios leves com aumento entre de 10-40 mg/L. Já em inflamações mais severas e infecções bacterianas, as concentrações séricas elevam-se entre 40-200 mg/L (Aguiara et al, 2013 Todos os parâmetros hematológicos dos cães examinados permaneceram dentro dos valores de referência.…”

Spending with unnecessary complementary tests for hypertension and diabetes in health services

“…(12) However, medical recommendations must be based on the epidemiological situation and on regularly reviewed protocols (13) , thus preventing the excess of laboratory test requests, which are expensive and could be better used in health services. (12) Therefore, in this context, the analyses of costs -whether they are related to materials, personnel, structure and/ or procedures -must result in streamlining and reducing costs, and also as a means of better using and prioritizing fi nancial resources in order to achieve eff ectiveness of health care services.…”