Proteinase imbalance in oral cancer and other diseases

Trino, Luciana D.; Granato, Daniela Campos; Neves, Leandro Xavier; Hansen, Hinrich P.; Leme, Adriana Franco Paes

doi:10.1016/b978-0-323-85696-6.00002-0

Proteolytic Signaling in Health and Disease 2022

DOI: 10.1016/b978-0-323-85696-6.00002-0

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Proteinase imbalance in oral cancer and other diseases

Luciana D. Trino¹,

Daniela Campos Granato²,

Leandro Xavier Neves³

et al.

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Cited by 1 publication

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Immunomodulatory role of metalloproteinase ADAM17 in tumor development

et al. 2022

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ADAM17 is a member of the a disintegrin and metalloproteinase (ADAM) family of transmembrane proteases involved in the shedding of some cell membrane proteins and regulating various signaling pathways. More than 90 substrates are regulated by ADAM17, some of which are closely relevant to tumor formation and development. Besides, ADAM17 is also responsible for immune regulation and its substrate-mediated signal transduction. Recently, ADAM17 has been considered as a major target for the treatment of tumors and yet its immunomodulatory roles and mechanisms remain unclear. In this paper, we summarized the recent understanding of structure and several regulatory roles of ADAM17. Importantly, we highlighted the immunomodulatory roles of ADAM17 in tumor development, as well as small molecule inhibitors and monoclonal antibodies targeting ADAM17.

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Immunomodulatory role of metalloproteinase ADAM17 in tumor development

et al. 2022

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Proteinase imbalance in oral cancer and other diseases

Cited by 1 publication

References 155 publications

Immunomodulatory role of metalloproteinase ADAM17 in tumor development

Immunomodulatory role of metalloproteinase ADAM17 in tumor development

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