Proteinases and eukaryotic cell growth

Scott, G. K.

doi:10.1016/0305-0491(87)90462-7

Cited by 5 publications

(3 citation statements)

References 78 publications

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“…Intracellular proteinases have a signifi cant role in the regulation of cellular proliferative processes [16]. The stimulative effect of SICRI and some other similar agents on the cell growth may be therefore related to (or even mediated by) modifica tion of activities of intracellular proteinases involved in the regulation of cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

Substance Immunologically Cross-Reactive with Insulin (SICRI) Stimulates Cell Division

Osmak

Sirotković²,

Levanat³

et al. 1989

Oncology

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A substance immunologically cross-reactive with insulin (SICRI) was isolated and purified from murine melanoma B16. Biochemical and biological data provide evidence that SICRI and insulin are two distinct biologically active agents. In vitro, SICRI has stimulated the DNA and protein synthesis, cell growth or colony-forming ability of 19 normal and transformed cell lines of human and rodent origin. It indicates that SICRI is a potent nonspecific growth factor. The most pronounced stimulatory effect of SICRI on proliferative capacity of cells is observed with cells at G_o/G₁ point of the cell cycle.

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Section: Discussionmentioning

confidence: 99%

Substance Immunologically Cross-Reactive with Insulin (SICRI) Stimulates Cell Division

Osmak

Sirotković²,

Levanat³

et al. 1989

Oncology

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“…It remains a possibility that the GBP and the GRP form adjacent links in a growthregulatory chain, though further experimental work is clearly necessary to establish or refute this hypothesis. If it is confirmed, it may still represent only a partial account of the action of the GRP; there is some evidence to suggest that there may be more than one substrate for this enzyme (Scott, 1987).…”

Section: (±12)mentioning

confidence: 99%

“…There is now a considerable body of evidence to show that endogenous proteinases are involved in the proliferation of many animal cells in culture (Scott, 1987). One enzyme, the so-called growth-related proteinase (GRP), was first isolated from human leukocyte membranes as a serine proteinase with a molecular weight of about 75,000.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of an endogenous growth‐related proteinase enhances the recovery of a negative growth regulator from cultured human cells.

Manilal

Scott

Tse

1993

Cell Biology International

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Changes of the surface proteolytic activity in synchronized Ehrlich ascites tumor cells grown in vivo

Adamietz

Hasler

Renner

et al. 1990

J Cancer Res Clin Oncol

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Changes of the cell surface proteolytic activity during the cell cycle in vitro were reported. Using an easy assay, with casein as a substrate, the proteolytic activity on the surface of Ehrlich ascites tumor (EAT) cells grown in vivo was determined. The cleavage of casein incubated with EAT cells increased linearly for 20 min and permitted reproducible enzyme activity determinations. If the proliferation of exponentially growing EAT cells was partially synchronized by an intraperitoneal bleomycin injection, a significant increase of the surface enzymatic activity was observed in cells with an increased DNA content. This finding supports the results obtained with transformed cells in vitro, indicating that elevated proteolytic surface activity occurs in the late synthesis phase and prior to mitosis. However, the observed effect may also be due to changes of gene expression caused by bleomycin.

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Proteinases and eukaryotic cell growth

Cited by 5 publications

References 78 publications

Substance Immunologically Cross-Reactive with Insulin (SICRI) Stimulates Cell Division

Substance Immunologically Cross-Reactive with Insulin (SICRI) Stimulates Cell Division

Inhibition of an endogenous growth‐related proteinase enhances the recovery of a negative growth regulator from cultured human cells.

Changes of the surface proteolytic activity in synchronized Ehrlich ascites tumor cells grown in vivo

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