Proteobacteria: microbial signature of dysbiosis in gut microbiota

Shin, Namsoo; Whon, Tae Woong; Bae, Jin‐Woo

doi:10.1016/j.tibtech.2015.06.011

Cited by 2,768 publications

(1,967 citation statements)

References 84 publications

Supporting

127

Mentioning

1,812

Contrasting

Unclassified

Order By: Relevance

“…Thus, it seems plausible that alteration of intestinal bacterial communities by RELMβ, particularly those that are most closely associated with host tissues, could have metabolic consequences. In particular, Proteobacteria (targeted by RELMβ) have been shown to contribute to changes in host metabolism (29,30).…”

Section: Discussionmentioning

confidence: 99%

Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium

Propheter

Chara

Harris

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

139

108

View full text Add to dashboard Cite

The mammalian intestine is colonized by trillions of bacteria that perform essential metabolic functions for their hosts. The mutualistic nature of this relationship depends on maintaining spatial segregation between these bacteria and the intestinal epithelial surface. This segregation is achieved in part by the presence of a dense mucus layer at the epithelial surface and by the production of antimicrobial proteins that are secreted by epithelial cells into the mucus layer. Here, we show that resistin-like molecule β (RELMβ) is a bactericidal protein that limits contact between Gram-negative bacteria and the colonic epithelial surface. Mouse and human RELMβ selectively killed Gram-negative bacteria by forming size-selective pores that permeabilized bacterial membranes. In mice lacking RELMβ, Proteobacteria were present in the inner mucus layer and invaded mucosal tissues. Another RELM family member, human resistin, was also bactericidal, suggesting that bactericidal activity is a conserved function of the RELM family. Our findings thus identify the RELM family as a unique family of bactericidal proteins and show that RELMβ promotes host-bacterial mutualism by regulating the spatial segregation between the microbiota and the intestinal epithelium.antibacterial protein | microbiota | innate immunity | intestinal epithelium

show abstract

Section: Discussionmentioning

confidence: 99%

Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium

Propheter

Chara

Harris

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

139

108

View full text Add to dashboard Cite

show abstract

“…For example, an HFD reduces populations in the phylum Bacteroidetes and increases both Firmicutes and Proteobacteria relative to control diets that are 10-15% kilocalories from fat with complex carbohydrates (starch) as the primary carbohydrate source (18,19). Bacteroidetes aid in promoting T cell-mediated immune responses in the host and prevent the overgrowth of more harmful pathogens (20)(21)(22), whereas Proteobacteria and Firmicutes are generally associated with gut dysbiosis (23) and obesity (24), respectively. However, given that rodent HFD models produce obesity and metabolic syndrome, it is unclear whether HFD-mediated gut microbiome alterations are based directly on dietary factors or, rather, are secondary to increased adiposity and associated metabolic derangements.…”

Section: Introductionmentioning

confidence: 99%

Early-Life Sugar Consumption Affects the Rat Microbiome Independently of Obesity

Noble

Hsu

Jones

et al. 2017

The Journal of Nutrition

View full text Add to dashboard Cite

show abstract

“…Methanogenic archaea, yeast, and viruses also appear in the composition of the intestinal microbiota [1,16]. Recently, it has been suggested that a greater proportion of Proteobacteria could be the microbial signature of dysbiosis in gut microbiota [17].…”

Section: The Gut Microbiotamentioning

confidence: 99%

The cross-talk between the kidney and the gut: implications for chronic kidney disease

Andrade

Ramos

Cuppari

2017

Nutrire

View full text Add to dashboard Cite

In recent decades, special attention has been given to the potential association between the gut ecosystem and chronic diseases. Several features and complications of chronic kidney disease (CKD) may induce an unbalanced gut environment, leading to unfavorable consequences for a patient's health. The first section of this review is dedicated to a description of some aspects of gut microbiota and intestinal barrier physiology. The following section explores the impact of CKD on the gut ecosystem and intestinal barrier, particularly the association with uremic toxins, inflammation, and immunodeficiency. Finally, the review describes the state of the art of potential therapies with prebiotics, probiotics, and synbiotics employed to modulate the gut environment and to reduce the generation of colon-derived uremic toxins in CKD.

show abstract

Proteobacteria: microbial signature of dysbiosis in gut microbiota

Cited by 2,768 publications

References 84 publications

Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium

Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium

Early-Life Sugar Consumption Affects the Rat Microbiome Independently of Obesity

The cross-talk between the kidney and the gut: implications for chronic kidney disease

Contact Info

Product

Resources

About