Proteolysis and therapeutic potential of bioactive peptides derived from Cheddar cheese

Shafique, Bakhtawar; Murtaza, Mian Anjum; Hafiz, Iram; Ameer, Kashif; Basharat, Shahnai; Ahmed, Isam A. Mohamed

doi:10.1002/fsn3.3501

Cited by 6 publications

(2 citation statements)

References 151 publications

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“…The type of milk used during cheese ripening, starter culture, and native milk microbiota affect the bioactive peptides formed. Bioactive peptides are composed of certain protein fragments and offer various advantages for regulating bodily processes [121][122][123].…”

Section: Cheesementioning

confidence: 99%

Certain Fermented Foods and Their Possible Health Effects with a Focus on Bioactive Compounds and Microorganisms

Deveci,

Çelik,

Ağagündüz

et al. 2023

Fermentation

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Fermented foods refer to beverages or foods made by carefully regulated microbial growth and the enzymatic conversion of dietary components. Fermented foods have recently become more popular. Studies on fermented foods suggest the types of bacteria and bioactive peptides involved in this process, revealing linkages that may have impacts on human health. By identifying the bacteria and bioactive peptides involved in this process, studies on fermented foods suggest relationships that may have impressions on human health. Fermented foods have been associated with obesity, cardiovascular disease, and type 2 diabetes. In this article, fermented dairy products, vegetables and fruits, legumes, meats, and grains are included. Two elements in particular are emphasized when discussing the fermentation of all of these foods: bioactive chemicals generated during fermentation and microorganisms involved during fermentation. Organic acids, bioactive peptides, conjugated linoleic acid, biogenic amines, isoflavones, phytoestrogens, and nattokinase are a few of the bioactive compounds included in this review. Also, certain bacteria such as Lactobacillus, Bifidobacterium, Streptococcus, and Bacillus species, which are utilized in the fermentation process are mentioned. The effects of both substances including anti-fungal and antioxidant properties; the modulation of intestinal microbiota; anti-inflammatory, antidiabetes, anti-obesity, anticancer, and antihypertension properties; and the protection of cognitive function are explained in this review.

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Section: Cheesementioning

confidence: 99%

Certain Fermented Foods and Their Possible Health Effects with a Focus on Bioactive Compounds and Microorganisms

Deveci,

Çelik,

Ağagündüz

et al. 2023

Fermentation

View full text Add to dashboard Cite

show abstract

“…Bioactive peptides, composed of 2–20 amino acids, contribute to biological activity and have a positive effect on human health (Hu, Pan et al, 2022 , Hu, Yang et al, 2022 ; Xu et al, 2020 ). Over the past few decades, bioactive peptides derived from natural resources, with low toxicity and cost but high degree of biological activity, have been reported to reduce or prevent chronic disease risk and provide immune protection (Shafique et al, 2023 ), and thus used as health and functional food to effectively modulate immune response (Cai et al, 2020 ; Milica et al, 2022 ; Ye et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Purification and characterization of a novel immunoregulatory peptide from Sipunculus nudus L. protein

Lin,

Li,

Sun

et al. 2023

Food Science & Nutrition

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This study aimed to purify and characterize immunoregulatory peptides from Sipunculus nudus L. and to explore the underlying mechanisms. Ultrafiltration, gel filtration chromatography, and reverse phase high‐performance liquid chromatography (RP‐HPLC) were used to purify the peptide following enzymatic hydrolysis. Rates of lymphocyte proliferation and phagocytosis as well as nitric oxide (NO) production levels were used as indicators of immunoregulatory activity to screen the fractions. The amino acid sequence of the peptide, designated as SNLP, was identified as Arg–Val–Lys–Gly–Lys–Ile–Leu–Ala–Lys–Arg–Leu–Asn (RVKGKILAKRLN) by liquid chromatography–tandem mass spectrometry (LC–MS/MS). Treatment with the synthetic SNLP increased the proliferation and phagocytosis of RAW 264.7 macrophages and promoted the secretion of tumor necrosis factor‐ɑ (TNF‐α), interleukin‐6 (IL‐6), interleukin‐1β (IL‐1β), and NO levels. The mRNA levels of these cytokines and iNOS were also increased by SNLP. Our results provide preliminary evidence suggesting that SNLP acts as a dual immunomodulatory peptide with immunostimulatory and anti‐inflammatory activities. In summary, SNLP derived from Sipunculus nudus L. is a potent immunoregulatory peptide and represents a potential functional food or immunoregulatory drug.

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Polysaccharide-Based Films: Carriers of Active Substances and Controlled Release Characteristics

Ameer,

Murtaza,

Zainab

et al. 2024

Polysaccharide Based Films for Food Packaging: Fundamentals, Properties and Applications

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Proteolysis and therapeutic potential of bioactive peptides derived from Cheddar cheese

Cited by 6 publications

References 151 publications

Certain Fermented Foods and Their Possible Health Effects with a Focus on Bioactive Compounds and Microorganisms

Certain Fermented Foods and Their Possible Health Effects with a Focus on Bioactive Compounds and Microorganisms

Purification and characterization of a novel immunoregulatory peptide from Sipunculus nudus L. protein

Polysaccharide-Based Films: Carriers of Active Substances and Controlled Release Characteristics

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