Proteolytic activation of anti-Müllerian hormone is suppressed in adolescent girls

Pankhurst, Michael W.; Dillingham, Peter W.; Peña, Alexia S

doi:10.1007/s12020-021-02955-z

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“…Some studies evaluating AMH in the diagnosis of adolescent PCOS have used Rotterdam criteria for PCOS diagnosis, which is not appropriate for adolescents [ 8 , 9 , 78 , 105 , 106 , 107 , 108 ]. The following studies have used PCOS NIH diagnosis criteria of irregular menstrual cycles and hyperandrogenism with inconsistent results in relation to AMH levels in adolescents with PCOS [ 109 , 110 , 111 , 112 ]. AMH levels are higher in non-obese [ 109 ] and obese adolescents with PCOS [ 111 , 113 , 114 ] and AMH levels decreased with weight loss and other treatments in adolescents with PCOS [ 68 , 114 , 115 ].…”

Section: Main Criteria To Diagnose Pcos During Adolescencementioning

confidence: 99%

Criteria for Diagnosis of Polycystic Ovary Syndrome during Adolescence: Literature Review

2022

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Polycystic ovary syndrome (PCOS) is one of the most common endocrine conditions in women. PCOS may be more challenging to diagnose during adolescence due to an overlap with the physiological events of puberty, which are part of the diagnostic criteria in adult women. This review focuses on the evidence available in relation to PCOS diagnostic criteria for adolescents. Adolescent PCOS should be diagnosed using two main criteria irregular -menstrual cycles (relative to number of years post-menarche) and hyperandrogenism (clinical and/or biochemical); after excluding other conditions that mimic PCOS. Accurate definitions of the two main criteria will decrease challenges/controversies with the diagnosis and provide timely diagnosis during adolescence to establish early management. Despite the attempts to create accurate diagnostic criteria and definitions, this review highlights the limited research in this area, especially in the follow up of adolescents presenting with one diagnostic feature that are called “at risk of PCOS”. Studies in adolescents continue to use the Rotterdam diagnostic criteria that uses pelvic ultrasound. This is inappropriate, because previous and emerging data that show many healthy adolescents have polycystic ovarian morphology in the early years post-menarche. In the future, anti-Müllerian hormone levels might help support PCOS diagnosis if adolescents meet two main criteria.

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