2024
DOI: 10.22141/2224-0713.20.5.2024.1089
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Proteolytic imbalance in plasma of patients with multiple sclerosis following COVID-19

T.I. Halenova,
N.G. Raksha,
T.B. Vovk
et al.

Abstract: Background. The present research was conducted with the following objectives: 1) to determine the plasma levels of five matrix metalloproteinases (MMPs), namely MMP-1, -2, -3, -8, -10, and tissue inhibitor of metalloproteinase-1 (TIMP-1); 2) to analyze protease activity profiles in plasma using a zymographic method; and 3) to perform preliminary analysis on plasma peptide pool composition in patients with multiple sclerosis (MS) with and without COVID-19 history. Materials and methods. We examined 97 patients … Show more

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