Proteolytic versus surgical removal: the therapeutic effect of fig tree latex (Ficus carica L) on cutaneous and diphtheric forms of avian pox in pigeons (Columba domestica)

Abid, Tanaz; Ali, Kh.

doi:10.33899/ijvs.2014.89471

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…This is the first time this compound was reported in F. botryocarpa. With consistent spectral data fractions (1), (2) and (3) are ficuseptine bearing different anionic components. These ficuseptine derivatives are extremely polar and cationic.…”

Section: Resultssupporting

confidence: 64%

“…Fruit latex of F. botryocarpa was used to treat sores, wounds and other superficial skin infections in East Sepik Province, Papua New Guinea (PNG) [1][2][3]. Staphylococci are the principal causative agents accounting for 30% to 50% of wound infections [4].…”

Section: Introductionmentioning

confidence: 99%

“…(F2) was confirmed as predominantly alkaloids by Dragendorff and Mayers test [8]. By means of preparative chromatography three fractions, (1), (2) and (3) were isolated from (F2). These fractions showed strong activity against Escherichia coli, S. aureus and two bacterial colonies types isolated from an infected folliculitis [9].…”

Section: Introductionmentioning

confidence: 99%

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Isolation of Three Bioactive Phenantroindolizidine Alkaloids from the Fruit Latex of Ficus botryocarpa Miq

Wau¹,

Timi²,

Harakuwe³

et al. 2015

Nat Prod Chem Res

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Latex of F. botryocarpa fruit is applied on skin infections in Papua New Guinea ethnotherapeutic practices. Systematic bioassay guided separation and isolation of subsequent fractions of latex extracts resulted in three bioactive fractions. Structures were determined by physical (M.pt and R f values) and spectroscopic (1D-1 H NMR, 2D-HSQC NMR, 2D-HMBC NMR) and MS ESI-POS. The two methylene protons (2H-1) and 2H-3) resonate as triplets at δ 3.59 and δ 4.99 respectively. Electron dense δ 4.99 (2H-3) on (C-3) depicts the strong electron withdrawing component, quaternary nitrogen (=N= +). Protons resonating at δ 3.88 and δ3.89 are singlets depicting two methoxy groups. Both δ 3.88 and δ 3.89 are para-aryls substituents. All isolates, (1), (2) and (3) were identified to be ficuseptine. 2D-NMR and MS of (2) found it to be ficuseptine chloride "2, 3-dihydro-6, 8-bis (4-methoxyphenyl)-1,2,3-trihydroindolizidinium chloride". The counter ions were not established and provide promising lead for further investigation.

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Section: Resultssupporting

confidence: 64%