2019
DOI: 10.1002/ijc.32556
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Proteome‐based classification of Nonmuscle Invasive Bladder Cancer

Abstract: DNA/RNA‐based classification of bladder cancer (BC) supports the existence of multiple molecular subtypes, while investigations at the protein level are scarce. Here, we aimed to investigate if Nonmuscle Invasive Bladder Cancer (NMIBC) can be stratified to biologically meaningful groups based on the proteome. Tissue specimens from 117 patients at primary diagnosis (98 with NMIBC and 19 with MIBC), were processed for high‐resolution proteomics analysis by liquid chromatography‐tandem mass spectrometry (LC‐MS/MS… Show more

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Cited by 44 publications
(45 citation statements)
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“…We also found that upregulated genes in the double-high group, consistent with Lindgren’s cluster 1, were involved in numerous themes of protein synthesis and metabolism [ 8 ]. Similarly, cytoskeletal, junctional, and cell interaction pathways supporting architecture integrity and metabolic pathways supporting homeostasis were found to be subtype-specific functions of an indolent NMIBC subtype discovered by proteome recently [ 27 ]. Thus, it is reasonable to speculate that the differentiation and tissue organization of the double-high group is maintained by active intercellular interactions that are enriched for epithelium morphogenesis, and cell-cell and cell-substrate binding functions.…”
Section: Discussionmentioning
confidence: 99%
“…We also found that upregulated genes in the double-high group, consistent with Lindgren’s cluster 1, were involved in numerous themes of protein synthesis and metabolism [ 8 ]. Similarly, cytoskeletal, junctional, and cell interaction pathways supporting architecture integrity and metabolic pathways supporting homeostasis were found to be subtype-specific functions of an indolent NMIBC subtype discovered by proteome recently [ 27 ]. Thus, it is reasonable to speculate that the differentiation and tissue organization of the double-high group is maintained by active intercellular interactions that are enriched for epithelium morphogenesis, and cell-cell and cell-substrate binding functions.…”
Section: Discussionmentioning
confidence: 99%
“…With the rapid development of sequencing, mass spectrometry and other techniques, studies based on genomics and transcriptome (17), epigenetics (18), proteomics (19) and other omics (20)(21)(22) will provide a new direction for the accurate diagnosis and treatment of bladder cancer. A good classification system should meet the following criteria: I.…”
Section: Traditional Classification and Molecular Subtyping Systemsmentioning
confidence: 99%
“…The first group (NPS1), with predominant pathology of high stage and grade tumors, overexpresses proteins related to immune and inflammatory reactions, cell proliferation and DNA damage response; the second group (NPS2) presented with mixed pathology tumors, and proteins implicated on epithelial to mesenchymal transition; finally, the third group (NPS3) presented predominant pathology of low stage and grade tumors, with luminal and differentiation markers. NPS1 had the closest proteomic profile of MIBC (72).…”
Section: Tissue Proteomicsmentioning
confidence: 99%