Proteome modifications of juvenile beluga (Huso huso) brain as an effect of dietary methylmercury

Antioxidant system breakdown in brain of feral golden grey mullet (Liza aurata) as an effect of mercury exposure

“…An alternative explanation concerns the selective inhibition of specific enzymatic antioxidants while others can keep their functionality. This idea is supported by Keyvanshokooh et al (2009) who investigated changes in the brain tissue's proteome of fish (Huso huso) in response to MeHg, reporting on one hand, an over-expression of a/b hydrolase superfamily (e.g., epoxide hydrolase), and, on the other, an inhibited expression of AKR superfamily that includes antioxidative enzymes involved in the protection against aldehydes.…”

“…Most studies on mercury-induced brain disorders carried out in fish concern freshwater species (Larose et al 2008) and they are limited to laboratory approaches where the uptake routes are alternatively restricted to waterborne or dietary exposure (Berntssen et al 2003;Keyvanshokooh et al 2009). The processes on the basis of neurotoxicity have not yet been explored before in feral marine fish.…”

Methylmercury can induce Parkinson’s-like neurotoxicity similar to 1-methyl-4- phenylpyridinium: a genomic and proteomic analysis on MN9D dopaminergic neuron cells

“…Even though the effects of MeHg or MPP + on protein or gene expression patterns in the context of neurotoxicity have been reported in previous studies (Keyvanshokooh et al, 2009;Vendrell et al, 2010;Xie et al, 2011), this is the first report to use both genomic and proteomic approach to study the effects of MeHg and its relationship with PD using a dopaminergic cell line. Using a known shown to be involved in PD pathogenesis.…”

“…Environmental pollutants such as pesticides and heavy metals have been reported to be possible risk factors leading to the pathogenesis of PD (Michalke et al, 2009;Roos et al, 2006). Methylmercury (MeHg) is one of the most toxic forms of mercury (Keyvanshokooh et al, 2009). MeHg causes damages to the nervous system in the early developmental stages as it alters both the structure and functionality of the nervous system (Grandjean et al, 2010).…”

Assessment of the accuracy of physiological blood indicators for the evaluation of stress, health status and welfare in Siberian sturgeon (Acipenser baerii) subject to chronic heat stress and dietary supplementation

“…The same trend was found in the literature with various sturgeon species and tissues (see Table 2 for details on species, tissues and HSP). HSP protein levels increase as a consequence of heat stress (Allen et al 2006;Deng et al 2009;Han et al 2012;LinaresCasenave et al 2013;Silvestre et al 2010;Wang et al 2013;Werner et al 2007;Zheng et al 2015), acute cold stress, air exposure (Wang et al 2013), and contamination (Keyvanshokooh et al 2009), but not during salinity acclimation (Sardella and Kültz 2009). Hsp mRNA expression increases with high stocking density or after an acute hypoxic stress (Ni et al 2014).…”