Proteomic analysis identified LBP and CD14 as key proteins in blood/biphasic calcium phosphate microparticle interactions

Proteomic Insights into Osteoporosis: Unraveling Diagnostic Markers of and Therapeutic Targets for the Metabolic Bone Disease

“…Similarly, a proteomic analysis of serum-derived exosomes from individuals with neurofibromatosis type 1 congenital tibial pseudarthrosis demonstrated their detrimental impact on bone by promoting osteoclastogenesis and inhibiting osteoblastogenesis [57]. Additionally, a proteomic investigation identified LBP and CD14 as pivotal proteins involved in interactions between blood and biphasic calcium phosphate microparticles [58]. These proteomic insights provide valuable knowledge of the molecular mechanisms underlying bone metabolism, offering potential targets for therapeutic interventions in OP [59][60][61][62].…”

CaO2–Cu2O micromotors accelerate infected wound healing through antibacterial functions, hemostasis, improved cell migration, and inflammatory regulation

“…Many references reported that calcium ions activated platelets and were responsible for the activation of many blood coagulation factors. 36,37,43,44 Thus, we evaluated the blood clotting effects of CaO 2 -Cu 2 O micromotors. The most rapid blood clotting was observed in the group treated with micromotors (3 min), followed by CaO 2 particles (5 min) and Cu 2 O particles (6 min) (Fig.…”

Autologous blood clots: a natural biomaterial for wound healing

“…The concentration of BCP within the BC appears to play a role in directing tissue differentiation. Jing et al demonstrated that, in mouse models, BCs containing 80-200 µm of BCP microparticles induced formation of ectopic woven bone, while concentrations of 200-500 µm induced mainly fibrous tissue (Jing et al, 2021). Such BCP-BC composites likely induce osteogenesis as they strongly upregulate the TLR4 signaling pathway and fibrinogen (FGN).…”

“…FGN acts upon TLR4 through MyD88-dependent nuclear factor-κB activation. BCP particles also induce production of proteins involved in the HGF and IGF osteogenic pathways, likely through the TLR4 signaling cascade (Jing et al, 2021). Therefore, modulating the concentration of BCP within autologous blood preparations to tissue-specific levels may provide further benefit in wound healing.…”