Proteomic analysis of extracellular vesicles from tick hemolymph and uptake of extracellular vesicles by salivary glands and ovary cells

Xu, Zhen; Wang, Yanan; Sun, Min; Zhou, Yongzhi; Cao, Jie; Zhang, Houshuang; Xuan, Xuenan; Zhou, Jinlin

doi:10.1186/s13071-023-05753-w

Cited by 7 publications

(1 citation statement)

References 94 publications

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“…While these ferritin cages are often several nanometers in diameter, the secretory Ferritin 2 was identified within larger (~ 100 nm) hemolymphatic extracellular vesicles in Rhipicephalus haemaphysaloides and Hya. asiaticum ticks (Xu et al 2023).…”

Section: Incomplete Heme Pathways and Heme-independent Iron Inter-tis...mentioning

confidence: 99%

Genome sequences of fourIxodesspecies expands understanding of tick evolution

de Araujo,

Noël,

Bretaudeau

et al. 2024

Preprint

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Ticks, hematophagous acari, pose a significant threat by transmitting various pathogens to their vertebrate hosts during feeding. Despite advances in tick genomics, high-quality genomes were lacking until recently, particularly in the genusIxodes, which includes the main vectors of Lyme disease. Here, we present the complete genome sequences of four tick species, derived from a single female individual, with a particular focus on the European speciesIxodes ricinus, achieving a chromosome-level assembly. Additionally, draft assemblies were generated for the three otherIxodesspecies,I. persulcatus, I. pacificusandI. hexagonus. The quality of the four genomes and extensive annotation of several important gene families have allowed us to study the evolution of gene repertoires at the level of the genusIxodesand of the tick group. We have determined gene families that have undergone major amplifications during the evolution of ticks, while an expression atlas obtained forI. ricinusreveals striking patterns of specialization both between and within gene families. Notably, several gene family amplifications are associated with a proliferation of single-exon genes. The integration of our data with existing genomes establishes a solid framework for the study of gene evolution, improving our understanding of tick biology. In addition, our work lays the foundations for applied research and innovative control targeting these organisms.

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Section: Incomplete Heme Pathways and Heme-independent Iron Inter-tis...mentioning

confidence: 99%