Proteomic analysis of Korean ginseng (Panax ginseng C.A. Meyer)

Nam, Myung Hee; Kim, Kyung Sik; Liu, Jang Ryol; Yang, Deok Chun; Lim, Yong Pyo; Kwon, Ki Young; Yoo, Jong Shin; Park, Young Mok

doi:10.1016/j.jchromb.2004.10.063

Cited by 66 publications

(49 citation statements)

References 61 publications

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“…More than forty ginsenosides have, so far, been isolated and each ginsenoside possesses different pharmacological effects. 22,24) Commercially available Korean ginseng products are classified into fresh ginseng, white ginseng, and red ginseng. Although both Korean red and white ginseng products are manufactured from the same 6-year-old fresh ginseng roots, Korean red ginseng has higher contents of ginsenosides such as Rg3, Rg5 and Rh2 than white ginseng, 23) and its extract exhibits significantly higher pharmacological effects on vascular regeneration.…”

Section: Discussionmentioning

confidence: 99%

Water Extract of Korean Red Ginseng Stimulates Angiogenesis by Activating the PI3K/Akt-Dependent ERK1/2 and eNOS Pathways in Human Umbilical Vein Endothelial Cells

Kim

Namkoong

Yun

et al. 2007

Biological & Pharmaceutical Bulletin

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Section: Discussionmentioning

confidence: 99%

Water Extract of Korean Red Ginseng Stimulates Angiogenesis by Activating the PI3K/Akt-Dependent ERK1/2 and eNOS Pathways in Human Umbilical Vein Endothelial Cells

Kim

Namkoong

Yun

et al. 2007

Biological & Pharmaceutical Bulletin

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“…Several in-vivo studies have suggested that ginseng may lower BP in a dose-independent manner [3,[9][10][11][12][13].…”

Section: Ginseng For Reducing the Blood Pressure In Patients With Hypmentioning

confidence: 99%

“…Ginseng is one of the most popular medicinal herbs [3]. Ginseng is claimed to be effective for wide range of conditions, such as cancer [4], erectile dysfunction [5], and postmenopausal symptoms [6].…”

Section: Introductionmentioning

confidence: 99%

Ginseng for Reducing the Blood Pressure in Patients with Hypertension: A Systematic Review and Meta-Analysis

Hur¹,

Lee²,

Yang³

et al. 2010

Journal of Ginseng Research

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Ginseng is one of the most-widely used herbal remedies. This systematic review evaluates the current evidence for its use in the reducing blood pressure (BP) in patients with hypertension. Systematic searches of 12 electronic databases were conducted without language restrictions. All randomized clinical trials (RCTs) of ginseng as a treatment for hypertension were candidates for inclusion. Methodological quality was assessed using the Cochrane risk of bias. Five RCTs met the inclusion criteria. The risk of bias was low in most of the trials. Four of the included RCTs compared the effectiveness of ginseng to placebo. The meta-analysis of these data failed to show a statistically significant acute effect on systolic BP (SBP) or diastolic BP (DBP). However, subgroup analyses showed beneficial effects of Korean red ginseng (KRG) on both SBP (n=54, mean difference [MD], -6.52; 95% confidence interval [CI], -9.99 to -3.04; p=0.0002) and DBP (n=54, MD, -5.21; 95% CI, -7.90 to-2.51; p=0.0001). Two RCTs tested the long-term effects of ginseng for BP for 24hours. One of these trials failed to show any benefits of KRG compared to no treatment, and the other failed to show superior effects of North American ginseng compared to placebo. Adverse events with ginseng were none in one trial or not assessed. Collectively, these RCTs provide limited evidence for the acute effectiveness of KRG in the treatment of high BP. The total number of RCTs included in the analysis and the total sample size were insufficient to draw definitive conclusions. More rigorous studies are warranted.

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“…[8][9][10] 20(S)-Ginsenoside Rh2 (GRh2), with a dammarane skeleton, belongs to the protopanaxadiol family and has drawn attention in chemopreventive research. [11][12][13] Recently, researchers have found that 20(S)-GRh2 exhibits anticancer effects and could inhibit growth of several cancer cell lines and induce apoptosis in mammalian tumor cells. [14][15][16] However, the details of the signal transduction cascade involved in 20(S)-GRh2-induced death in Reh cells remaine unclear.…”

mentioning

confidence: 99%

20(<i>S</i>)-Ginsenoside Rh2 Induces Apoptosis in Human Leukaemia Reh Cells through Mitochondrial Signaling Pathways

Xia

Wang

et al. 2014

Biological & Pharmaceutical Bulletin

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Proteomic analysis of Korean ginseng (Panax ginseng C.A. Meyer)

Cited by 66 publications

References 61 publications

Water Extract of Korean Red Ginseng Stimulates Angiogenesis by Activating the PI3K/Akt-Dependent ERK1/2 and eNOS Pathways in Human Umbilical Vein Endothelial Cells

Water Extract of Korean Red Ginseng Stimulates Angiogenesis by Activating the PI3K/Akt-Dependent ERK1/2 and eNOS Pathways in Human Umbilical Vein Endothelial Cells

Ginseng for Reducing the Blood Pressure in Patients with Hypertension: A Systematic Review and Meta-Analysis

20(<i>S</i>)-Ginsenoside Rh2 Induces Apoptosis in Human Leukaemia Reh Cells through Mitochondrial Signaling Pathways

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