Proteomic analysis of masticatory muscle tendon–aponeurosis hyperplasia: A preliminary study using a 2D-DIGE system

Masticatory muscle tendon‐aponeurosis hyperplasia exhibits heterotopic calcification in tendons

“…However, the aberrant sound heard on cutting tendon tissues with scissors during operation indicates hardness of tendon tissues, suggesting that anomalous changes do occur (Kakudo and Yoda, ). We previously performed a pilot study using a two‐dimensional fluorescence difference gel electrophoresis (2D‐DIGE) system to identify candidate molecules as potential diagnostic markers in MMTAH and found that some proteins were up‐regulated in MMTAH as compared with the patients who had facial deformity (FD) with normal tendons (Sato et al , ). Masticatory muscle tendon‐aponeurosis hyperplasia progresses bilaterally and is a juvenile‐onset disease.…”

Possible association of oestrogen and Cryba4 with masticatory muscle tendon‐aponeurosis hyperplasia

“…In the masseter aponeurosis, COL6 is also observed from osseous attachment to the myotendinous junction (Senga et al., ). We also demonstrated that collagen type VI alpha 1 (COL6A1) was more highly expressed in the tendon and aponeurosis of patients with MMTAH than in those with facial deformity (Sato et al., ).…”

Masticatory muscle tendon-aponeurosis hyperplasia accompanied by limited mouth opening

“…Moreover, according to a proteomic analysis of the temporalis muscle tendon of MMTAH patients and in comparison to FD, fibrinogen fragment D and β-crystallinA4 (CRYBA4) were upregulated, while myosin light chain 4 (MYL4) was downregulated in MMTAH patients1920. Inactivation of myosin II causes abnormalities in the collagen fibers of the tendon along with downregulation of MYL4, suggesting that MYL4 reduction is associated with pathological conditions in MMTAH.…”