Proteomic analysis of microbial infections

Zhang, Lijie; Xiao, Di; Cheng, Keding

doi:10.1016/b978-0-12-818619-0.00106-4

Molecular Medical Microbiology 2024

DOI: 10.1016/b978-0-12-818619-0.00106-4

|View full text |Cite

Proteomic analysis of microbial infections

Lijie Zhang,

Di Xiao,

Keding Cheng

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Beyond the Gut: The intratumoral microbiome's influence on tumorigenesis and treatment response

Zhang,

Fu,

Leiliang

et al. 2024

Cancer Communications

View full text Add to dashboard Cite

The intratumoral microbiome (TM) refers to the microorganisms in the tumor tissues, including bacteria, fungi, viruses, and so on, and is distinct from the gut microbiome and circulating microbiota. TM is strongly associated with tumorigenesis, progression, metastasis, and response to therapy. This paper highlights the current status of TM. Tract sources, adjacent normal tissue, circulatory system, and concomitant tumor co‐metastasis are the main origin of TM. The advanced techniques in TM analysis are comprehensively summarized. Besides, TM is involved in tumor progression through several mechanisms, including DNA damage, activation of oncogenic signaling pathways (phosphoinositide 3‐kinase [PI3K], signal transducer and activator of transcription [STAT], WNT/β‐catenin, and extracellular regulated protein kinases [ERK]), influence of cytokines and induce inflammatory responses, and interaction with the tumor microenvironment (anti‐tumor immunity, pro‐tumor immunity, and microbial‐derived metabolites). Moreover, promising directions of TM in tumor therapy include immunotherapy, chemotherapy, radiotherapy, the application of probiotics/prebiotics/synbiotics, fecal microbiome transplantation, engineered microbiota, phage therapy, and oncolytic virus therapy. The inherent challenges of clinical application are also summarized. This review provides a comprehensive landscape for analyzing TM, especially the TM‐related mechanisms and TM‐based treatment in cancer.

show abstract

Beyond the Gut: The intratumoral microbiome's influence on tumorigenesis and treatment response

Zhang,

Fu,

Leiliang

et al. 2024

Cancer Communications

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Proteomic analysis of microbial infections

Cited by 1 publication

References 56 publications

Beyond the Gut: The intratumoral microbiome's influence on tumorigenesis and treatment response

Beyond the Gut: The intratumoral microbiome's influence on tumorigenesis and treatment response

Contact Info

Product

Resources

About