Proteomic analysis of the effects of cocaine on the enhancement of HIV-1 replication in normal human astrocytes (NHA)

Reynolds, Jessica L.; Mahajan, Supriya D.; Bindukumar, B.; Sykes, Donald E.; Schwartz, Stanley A.; Nair, Madhavan

doi:10.1016/j.brainres.2006.09.034

Cited by 58 publications

(57 citation statements)

References 69 publications

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“…Beta catenin is another gene that has been routinely reported in microarray studies as regulated by cocaine (i.e., Freeman et al 2001a;Zhang et al 2002;Novikova et al 2005) and recent work suggests that the D1 receptor is a critical mediator for cocaine-induced expression of this gene (Zhang et al 2002). Other genes identified here that have been previously shown to be involved in cocaine reward/regulated by cocaine include, Hivep2 (Reynolds et al 2006), Rxrb (Krezel et al 1998), and Chgb (Che et al 2006). Interestingly, the findings of regulation of Fdft1 and CamkIg are consistent with recent work in human cocaine, cannabis, and PCP abusers (Lehrmann et al 2006) suggesting that these genes may represent common molecular features of drug addiction.…”

Section: Cocaine-responsive Gene Expression Of Non-circadian Genesmentioning

confidence: 66%

Gene profiling the response to repeated cocaine self-administration in dorsal striatum: A focus on circadian genes

et al. 2008

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Alterations in gene expression in the dorsal striatum caused by chronic cocaine exposure have been implicated in the long-term behavioral changes associated with cocaine addiction. To gain further insight into the molecular alterations that occur as a result of cocaine self-administration, we conducted a microarray analysis of gene expression followed by bioinformatic gene network analysis that allowed us to identify adaptations at the level of gene expression as well as into interconnected networks. Changes in gene expression were examined in the dorsal striatum of rats 1 day after they had self-administered cocaine for 7 days under a 24-hr access, discrete trial paradigm (averaging 98 mg/kg/day). Here we report the regulation of the circadian genes Clock, Bmal1, Cryptochrome1, Period2, as well as several genes that are regulated by/associated with the circadian system (i.e., early growth response 1, dynorphin). We also observed regulation of other relevant genes (i.e., Nur77, beta catenin). These changes were then linked to curated pathways and formulated networks which identified circadian rhythm processes as affected by cocaine self-administration. These data strongly suggest involvement of circadian-associated genes in the brain's response to cocaine and may contribute to an understanding of addictive behavior including disruptions in sleep and circadian rhythmicity. Classification Molecular Brain Research SectionDisease-Related Neuroscience

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Section: Cocaine-responsive Gene Expression Of Non-circadian Genesmentioning

confidence: 66%

Gene profiling the response to repeated cocaine self-administration in dorsal striatum: A focus on circadian genes

et al. 2008

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“…They also found that a single administration of cocaine could lead to an alteration of the expression of multiple proteins in this brain region. It was also found that cocaine can enhance the replication of HIV-1 in normal human astrocytes; multiple proteins involved in different pathways are modulated in this process [45].…”

Section: Cocainementioning

confidence: 98%

Genes and Pathways Co-associated with the Exposure to Multiple Drugs of Abuse, Including Alcohol, Amphetamine/Methamphetamine, Cocaine, Marijuana, Morphine, and/or Nicotine: a Review of Proteomics Analyses

Wang

Yuan

2011

Mol Neurobiol

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Drug addiction is a chronic neuronal disease. In recent years, proteomics technology has been widely used to assess the protein expression in the brain tissues of both animals and humans exposed to addictive drugs. Through this approach, a large number of proteins potentially involved in the etiology of drug addictions have been identified, which provide a valuable resource to study protein function, biochemical pathways, and networks related to the molecular mechanisms underlying drug dependence. In this article, we summarize the recent application of proteomics to profiling protein expression patterns in animal or human brain tissues after the administration of alcohol, amphetamine/methamphetamine, cocaine, marijuana, morphine/heroin/butorphanol, or nicotine. From available reports, we compiled a list of 497 proteins associated with exposure to one or more addictive drugs, with 160 being related to exposure to at least two abused drugs. A number of biochemical pathways and biological processes appear to be enriched among these proteins, including synaptic transmission and signaling pathways related to neuronal functions. The data included in this work provide a summary and extension of the proteomics studies on drug addiction. Furthermore, the proteins and biological processes highlighted here may provide valuable insight into the cellular activities and biological processes in neurons in the development of drug addiction.

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“…Total RNA was extracted from zebrafish brains using Trizol, according to the manufacturer's protocol (Invitrogen), and 0.5 μg was reverse transcribed using 100 U Superscript III RT (Invitrogen) at 50°C for 60 min and 5 pmol oligo (dT) 16 . RealTime quantitative PCR using SYBR/GREEN I NUCLEIC A dye (Invitrogen) was performed with ABI 7500 fast (Applied Biosystems).…”

Section: Real-time Rt-pcrmentioning

confidence: 99%

“…Recently, 2D-PAGE, in combination with mass spectrometry has been widely used in the identification of specific biochemical markers for diagnostic, preventive and therapeutic intervention in drug addiction, including morphine [11][12][13][14][15], cocaine [16][17][18], nicotine [19,20], heroin [21], alcohol [22,23] and butorphanol [24]. The neurotoxic effects of drug abuse are often associated with oxidative stress, mitochondrial dysfunction, apoptosis and inhibition of neurogenesis, among other mechanisms [25].…”

Section: Introductionmentioning

confidence: 99%

Effects of chronic tramadol exposure on the zebrafish brain: A proteomic study

Zhuo

Huang

et al. 2012

Journal of Proteomics

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Proteomic analysis of the effects of cocaine on the enhancement of HIV-1 replication in normal human astrocytes (NHA)

Cited by 58 publications

References 69 publications

Gene profiling the response to repeated cocaine self-administration in dorsal striatum: A focus on circadian genes

Gene profiling the response to repeated cocaine self-administration in dorsal striatum: A focus on circadian genes

Genes and Pathways Co-associated with the Exposure to Multiple Drugs of Abuse, Including Alcohol, Amphetamine/Methamphetamine, Cocaine, Marijuana, Morphine, and/or Nicotine: a Review of Proteomics Analyses

Effects of chronic tramadol exposure on the zebrafish brain: A proteomic study

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