Proteomic dataset of Candida albicans (ATCC 10231) Biofilm

Zore, Gajanan; Abdulghani, Mazen; Kazi, Rubina; Shelar, Amruta; Patil, Rajendra

doi:10.1186/s13104-023-06436-6

BMC Res Notes

2023

DOI: 10.1186/s13104-023-06436-6

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Proteomic dataset of Candida albicans (ATCC 10231) Biofilm

Gajanan Zore

Mazen Abdulghani

Rubina Kazi

et al.

Abstract: Objectives The ability to form biofilm is considered as one of major virulence factors of Candida albicans, as biofilms form growth confers antifungal resistance and facilitate immune evasion. It is intriguing to understand morphophysiological modulations in the C. albicans cells growing under biofilm form growth. Data description In present study, we have profiled biofilm-specific proteins using LC-MS/MS analysis. Whole cell proteins of C. albican… Show more

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Cited by 3 publications

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Synthesis, design, and antimicrobial activity of pyrido[2,3‐d][1,2,4]triazolo[4,3‐a]pyrimidinones based on quinoline derivatives

Abu‐Hashem,

Yousif,

El‐Gazzar

et al. 2023

J Chinese Chemical Soc

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The pyrido[2,3‐d]pyrimidine moieties are one of the most biologically widespread heterocyclic compounds as antimicrobial, antioxidant, antitubercular, antiviral and anti‐inflammatory. Hence, we synthesized an efficient new series of 2‐thioxo‐pyrido[2,3‐d]pyrimidinone, 2‐hydrazinyl‐(quinolin‐2‐yl)pyrido[2,3‐d]pyrimidinone,N′‐(quinolin‐2‐yl)‐pyrido[2,3‐d]pyrimidine‐(formo/aceto)‐hydrazide and substituted‐(quinolin‐2‐yl)pyrido[2,3‐d][1,2,4]triazolo[4,3‐a]pyrimidinone derivatives. The characterization of new compounds was corresponded by using spectroscopic techniques, IR, NMR and Mass spectra. In vitro, all compounds were evaluated as antimicrobial activity compared with cefotaxime sodium and nystatin as the standard drug. This work deals with the exploration of the new heterocyclic compounds and medicinal diversity of quinoline‐pyrido[2,3‐d][1,2,4]triazolo[4,3‐a]pyrimidine derivatives that might pave the way for long in the discovery of therapeutic medicine for future drug design.

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Synthesis, design, and antimicrobial activity of pyrido[2,3‐d][1,2,4]triazolo[4,3‐a]pyrimidinones based on quinoline derivatives

Abu‐Hashem,

Yousif,

El‐Gazzar

et al. 2023

J Chinese Chemical Soc

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Proteomics characterization of biofilm formation by salt-tolerant Schwannyomyces etchellsii in seawater-based growth medium

Andreu,

del Olmo

2024

Current Research in Biotechnology

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Candida albicans cells exhibit media specific proteomic profiles during induction of filamentation

Véronique,

Guillaume

et al. 2024

BMC Microbiol

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Candida albicans is an opportunist pathogen responsible for a broad spectrum of infections, from superficial mycosis to the systemic disease candidiasis. C. albicans has various morphological forms, including unicellular budding yeasts, filamentous pseudohyphae and true hyphae, and the ability to switch from yeast to hyphal forms is a key survival mechanism underlying the adaptation of the pathogen to the microenvironments encountered within the host. Filamentation is regulated by multiple signalling pathways and its induction in different growth media in vitro has often led to conflicting results. In this study, we performed quantitative proteomic analyses to compare the response of C. albicans yeast cells grown in YNB minimal medium to those of cells grown in four media widely used in the literature to induce the yeast-to-hyphae transition: YNB-Serum, YNB-N-acetylglucosamine (YNB-NAG), Lee medium and rich Spider medium. We show that each growth medium induces a unique pattern of response in C. albicans cells, and that some conditions trigger an original and specific adaptive metabolic response, showing significant differences in the intracellular content of the various filamentous forms. Moreover, this comparison of proteomic profiles indicates that the medium used can modify the thiol-dependent redox status of the cells, particularly in YNB-Serum and Lee medium and, to a lesser extent, in Spider medium, confirming the role of oxidative stress in the filamentation process. Overall, our data indicate that some of the media routinely used to induce hyphae cause significant changes in proteomic signature that should be taken account more carefully when exploring the hyphal transition in this pathogen. Supplementary Information The online version contains supplementary material available at 10.1186/s12866-024-03627-4.

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Proteomic dataset of Candida albicans (ATCC 10231) Biofilm

Cited by 3 publications

References 8 publications

Synthesis, design, and antimicrobial activity of pyrido[2,3‐d][1,2,4]triazolo[4,3‐a]pyrimidinones based on quinoline derivatives

Synthesis, design, and antimicrobial activity of pyrido[2,3‐d][1,2,4]triazolo[4,3‐a]pyrimidinones based on quinoline derivatives

Proteomics characterization of biofilm formation by salt-tolerant Schwannyomyces etchellsii in seawater-based growth medium

Candida albicans cells exhibit media specific proteomic profiles during induction of filamentation

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